Dietary Effects on Coagulation Factor VII Vary across Genotypes of the R/Q353 Polymorphism in Elderly People

Manuscript received 7 August 1997. Initial reviews completed 25 November 1997. Revision accepted 24 January 1998.

Louise I. Mennen^{*, ,} , Moniek P. M. de Maat^**, Evert G. Schouten, Cornelis Kluft^**, Jacqueline C. M. Witteman^*, Albert Hofman^*, and Diederick E. Grobbee^*,

^* Department of Epidemiology and Biostatistics, Erasmus University, Rotterdam, 3000 DR Rotterdam, The Netherlands;  Division of Human Nutrition and Epidemiology, Agricultural University Wageningen, 6700 EV Wageningen, The Netherlands; ^** Gaubius Laboratory, TNO-PG, 2300 AK Leiden, The Netherlands; and  Julius Center for Patient Oriented Research, Utrecht University, 3508 TA Utrecht, The Netherlands

The objective of this study was to evaluate the association of factor VII with dietary factors while also considering the R/Q353 polymorphism. Nutrition is an important determinant of coagulation factor VII, which is also genetically determined by the R/Q353 polymorphism. High levels of coagulation factor VII clotting activity (FVII:C) are associated with the risk of myocardial infarction; nutrition may have an effect on these levels if people are genetically susceptible to dietary changes. FVII:C was measured in 3005 elderly subjects, and the extreme quintiles of the FVII:C distribution were selected for measurement of the R/Q353 genotype and FVII:Chr (reflects total factor VII). In these 1158 subjects, habitual diet was assessed with a semiquantitative food-frequency questionnaire. The frequency of the Q353 allele was 0.24 in the lowest and 0.09 in the highest quintile. The quintiles were combined for linear regression analyses. FVII:C was inversely associated with fiber [ = 0.64 %pooled plasma (PP)/g, confidence interval (CI): 1.07,0.21] and protein intake ( = 0.16 %PP/g, CI: 0.31,0.01) and positively with saturated fat intake ( = 0.19 %PP/g, CI: 0.10,0.48). FVII:Chr was inversely associated with fiber ( = 0.38 %PP/g, CI: 0.71,0.05). No other associations with diet were observed. The inverse association of FVII:C with fiber was stronger in subjects with the RR genotype ( = 0.76 %PP/g, CI: 1.23,0.29), than in those with the RQ/QQ genotypes ( = 0.19 %PP/g, CI: 0.97,0.59). The same was found for FVII:Chr. The association of FVII:C with saturated fat was positive in those with the RR allele and inverse in those carrying the Q allele. These findings suggest that the strength of the association between coagulation factor VII and diet varies across the genotypes of the R/Q353 polymorphism.

The Journal of Nutrition Vol. 128 No. 5 May 1998, pp. 870-874
Copyright ©1998 by the American Society for Nutritional Sciences

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