![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Manuscript received 24 June 1997. Initial reviews completed 5 August 1997. Revision accepted 4 December 1997.
Department of Pediatrics, Division of Neonatology and * Department of Anatomy, University of South Florida College of Medicine, Tampa, FL 33612
The effect of pre- and postnatal maternal dietary fatty acid composition on neurodevelopment in rat pups was studied. Timed pregnant dams were fed, beginning on d 2 of gestation and throughout lactation, either nonpurified diet (reference) or a purified diet whose fat source (22% of energy) was either corn oil or menhaden fish oil. On postnatal d 3, pups were randomly cross-fostered among dams of the same diet group and culled to 10 pups per dam. Milk was removed from stomachs of culled pups for fatty acid analyses. From postnatal d 4 to 30, pups were assessed daily for the appearance of neurodevelopmental reflexes. Auditory brainstem conduction times were measured on postnatal d 23 and 29. Pups were killed on postnatal d 30, and cerebrums were removed for fatty acid analyses. The fatty acid composition of maternal milk and pup cerebrums reflected maternal diet with higher levels of (n-3) and (n-6) fatty acids in the fish oil and corn oil groups, respectively. The time of appearance of auditory startle was significantly delayed (P = 0.004), and auditory brainstem conduction times on postnatal d 23 and 29 were significantly longer in pups of the fish oil- than corn oil-fed dams (P 
0.05). A delay in the appearance of the auditory startle reflex and longer auditory brainstem conduction times in pups of dams fed fish oil-supplemented diet may be due to negative effects on myelination of the auditory brainstem pathway.
The Journal of Nutrition Vol. 128 No. 4 April 1998,
pp. 740-743
Copyright ©1998 by the American Society for Nutritional Sciences
This article has been cited by other articles:
|
|
 |
|
  J. Bassaganya-Riera, A. J Guri, A. M Noble, K. A Reynolds, J. King, C. M Wood, M. Ashby, D. Rai, and R. Hontecillas Arachidonic acid and docosahexaenoic acid enriched formulas modulate antigen-specific T cell responses to influenza virus in neonatal piglets Am. J. Clinical Nutrition, March 1, 2007; 85(3): 824 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Olivo and L. Hilakivi-Clarke Opposing effects of prepubertal low- and high-fat n-3 polyunsaturated fatty acid diets on rat mammary tumorigenesis Carcinogenesis, September 1, 2005; 26(9): 1563 - 1572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Korotkova, B. Gabrielsson, M. Lonn, L.-A. Hanson, and B. Strandvik Leptin levels in rat offspring are modified by the ratio of linoleic to {alpha}-linolenic acid in the maternal diet J. Lipid Res., October 1, 2002; 43(10): 1743 - 1749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Innis and S. de la Presa Owens Dietary Fatty Acid Composition in Pregnancy Alters Neurite Membrane Fatty Acids and Dopamine in Newborn Rat Brain J. Nutr., January 1, 2001; 131(1): 118 - 122. [Abstract] [Full Text]
|
|
|
|
|
|
E. Amusquivar, F. J. Ruperez, C. Barbas, and E. Herrera Low Arachidonic Acid Rather than {alpha}-Tocopherol Is Responsible for the Delayed Postnatal Development in Offspring of Rats Fed Fish Oil Instead of Olive Oil during Pregnancy and Lactation J. Nutr., November 1, 2000; 130(11): 2855 - 2865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Wainwright, H.-C. Xing, G. R. Ward, Y.-S. Huang, E. Bobik, N. Auestad, and M. Montalto Water Maze Performance Is Unaffected in Artificially Reared Rats Fed Diets Supplemented with Arachidonic Acid and Docosahexaenoic Acid J. Nutr., May 1, 1999; 129(5): 1079 - 1089. [Abstract] [Full Text]
|
|
