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Regulation of Fetal Amino Acid Metabolism: Substrate or Hormonal Regulation?

Edward A. Liechty and Scott C. Denne

Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202

Insulin is regarded as the primary fetal growth-promoting hormone, but direct in vivo experimental data supporting this conjecture are sparse. Data obtained from studies in in vivo, chronically catheterized fetal lambs under a variety of experimental circumstances demonstrate that glucose availability is the primary modulator of fetal protein accretion, via its ability to diminish amino acid catabolism. The ovine fetus is shown to be resistant to insulin-induced suppression of proteolysis, relative to the adult. Data from studies in the human premature infant show that the findings in the ovine fetus are similar to those in the ex utero premature human.

Key words: insulin, ovine fetus, leucine, tracer kinetics, human premature infant.

The Journal of Nutrition Vol. 128 No. 2 February 1998, pp. 342S-346S
Copyright ©1998 by the American Society for Nutritional Sciences




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