Journal of Nutrition

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The Porcine Insulin-Like Growth Factor System: At the Interface of Nutrition, Growth and Reproduction

Frank A. Simmen*, , Lokenga Badingadagger , Michael L. Greendagger , Inseok Kwak*, Sihong Song*, , and Rosalia C. M. Simmendagger

* Department of Dairy and Poultry Sciences, dagger  Department of Animal Science, and the Interdisciplinary Concentration in Animal Molecular and Cell Biology, University of Florida, Gainesville, FL 32611-0920

The IGF system is implicated in the regulation of cellular response to protein- and energy-restriction. Although it is clear that the IGF and their binding proteins are profoundly influenced by dietary factors, a number of important questions remain about this relationship. In particular, although studies to date have focused on nutritional modulation of hepatic IGF gene expression, the molecular mechanisms underlying metabolic regulation of liver IGF and IGF binding protein genes remain relatively unknown. Moreover, the potential effects of altered nutrition on the expression and/or actions of IGF system components in tissues other than the liver have been examined only in cursory fashion. Many of these studies have used rats, an admittedly important model, but one which differs from the human in a potentially significant way: rats lack circulating IGF-II and IGFBP-2 during post-weaning and adult life. Here, we summarize current research on the porcine IGF system and highlight the particular usefulness this system may offer for unraveling the complex relationships of nutrition and systemic/local IGF expression and actions that are relevant to human nutritional physiology.

Key words: insulin-like, IGF-binding protein, regulation, gene, porcine.

The Journal of Nutrition Vol. 128 No. 2 February 1998, pp. 315S-320S
Copyright ©1998 by the American Society for Nutritional Sciences




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