![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Manuscript received 22 May 1997. Initial reviews completed 1 July 1997. Revision accepted 31 October 1997.
Department of Public Health, Gifu University School of Medicine, Gifu 500, Japan
The relationship between soy product intake and serum total cholesterol concentration was examined in 1242 men and 3596 women who participated in an annual health check-up program in Takayama City, Japan, provided by the municipality in 1992. The intake of soy products and various foods and nutrients was assessed by a semiquantitative food-frequency questionnaire. Blood samples were collected from fasting subjects to measure the serum total cholesterol concentration. A significant trend (P for trend = 0.0001) was observed for decreasing total cholesterol concentration with an increasing intake of soy products in men after controlling for age, smoking status and intake of total energy, total protein and total fat. This negative trend (P for trend = 0.0001) was also noted in women after controlling for age, menopausal status, body mass index and intake of total energy and vitamin C. An additional adjustment for physical activity, coffee and tea consumption, and intake of cholesterol, carbohydrates, fiber and vitamin E did not change the results. These data suggest a role for soy products in human cholesterol homeostasis.
Key words: cholesterol, soy products, diet, Japan, humans.
The Journal of Nutrition Vol. 128 No. 2 February 1998,
pp. 209-213
Copyright ©1998 by the American Society for Nutritional Sciences
This article has been cited by other articles:
|
|
 |
|
  S.-C. Yang, S.-M. Liu, H.-Y. Yang, Y.-H. Lin, and J.-R. Chen Soybean Protein Hydrolysate Improves Plasma and Liver Lipid Profiles in Rats Fed High-Cholesterol Diet J. Am. Coll. Nutr., October 1, 2007; 26(5): 416 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Clerici, K. D. R. Setchell, P. M. Battezzati, M. Pirro, V. Giuliano, S. Asciutti, D. Castellani, E. Nardi, G. Sabatino, S. Orlandi, et al. Pasta Naturally Enriched with Isoflavone Aglycons from Soy Germ Reduces Serum Lipids and Improves Markers of Cardiovascular Risk J. Nutr., October 1, 2007; 137(10): 2270 - 2278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. R Matthan, S. M Jalbert, L. M Ausman, J. T Kuvin, R. H Karas, and A. H Lichtenstein Effect of soy protein from differently processed products on cardiovascular disease risk factors and vascular endothelial function in hypercholesterolemic subjects Am. J. Clinical Nutrition, April 1, 2007; 85(4): 960 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Manjanatha, S. Shelton, M. E. Bishop, L. E. Lyn-Cook, and A. Aidoo Dietary effects of soy isoflavones daidzein and genistein on 7,12-dimethylbenz[a]anthracene-induced mammary mutagenesis and carcinogenesis in ovariectomized Big Blue(R) transgenic rats. Carcinogenesis, December 1, 2006; 27(12): 2555 - 2564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dewell, P. L. W. Hollenbeck, and C. B. Hollenbeck A Critical Evaluation of the Role of Soy Protein and Isoflavone Supplementation in the Control of Plasma Cholesterol Concentrations J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 772 - 780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yang, Z. T. Zhou, and J. P. Ge Effect of genistein on DMBA-induced oral carcinogenesis in hamster Carcinogenesis, March 1, 2006; 27(3): 578 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L McVeigh, B. L Dillingham, J. W Lampe, and A. M Duncan Effect of soy protein varying in isoflavone content on serum lipids in healthy young men Am. J. Clinical Nutrition, February 1, 2006; 83(2): 244 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Melby, M. Lock, and P. Kaufert Culture and symptom reporting at menopause Hum. Reprod. Update, September 1, 2005; 11(5): 495 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Messina and J. W Erdman Jr Need to establish threshold soy protein intake for cholesterol reduction Am. J. Clinical Nutrition, April 1, 2005; 81(4): 942 - 943. [Full Text] [PDF]
|
|
|
|
|
|
J. A. Nettleton, K. A. Greany, W. Thomas, K. E. Wangen, H. Adlercreutz, and M. S. Kurzer The Effect of Soy Consumption on the Urinary 2:16-Hydroxyestrone Ratio in Postmenopausal Women Depends on Equol Production Status but Is Not Influenced by Probiotic Consumption J. Nutr., March 1, 2005; 135(3): 603 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. T. van der Schouw, L. Sampson, W. C. Willett, and E. B. Rimm The Usual Intake of Lignans but Not That of Isoflavones May Be Related to Cardiovascular Risk Factors in U.S. Men J. Nutr., February 1, 2005; 135(2): 260 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vega-Lopez, K.-J. Yeum, J. L Lecker, L. M Ausman, E. J Johnson, S. Devaraj, I. Jialal, and A. H Lichtenstein Plasma antioxidant capacity in response to diets high in soy or animal protein with or without isoflavones Am. J. Clinical Nutrition, January 1, 2005; 81(1): 43 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S Rosell, P. N Appleby, E. A Spencer, and T. J Key Soy intake and blood cholesterol concentrations: a cross-sectional study of 1033 pre- and postmenopausal women in the Oxford arm of the European Prospective Investigation into Cancer and Nutrition Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1391 - 1396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Nagata, N. Takatsuka, N. Shimizu, and H. Shimizu Sodium Intake and Risk of Death From Stroke in Japanese Men and Women Stroke, July 1, 2004; 35(7): 1543 - 1547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Erdman Jr., T. M. Badger, J. W. Lampe, K. D.R. Setchell, and M. Messina Not All Soy Products Are Created Equal: Caution Needed in Interpretation of Research Results J. Nutr., May 1, 2004; 134(5): 1229S - 1233S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. H. Takimoto, K. Glover, X. Huang, S. A. Hayes, L. Gallot, M. Quinn, B. D. Jovanovic, A. Shapiro, L. Hernandez, A. Goetz, et al. Phase I Pharmacokinetic and Pharmacodynamic Analysis of Unconjugated Soy Isoflavones Administered to Individuals with Cancer Cancer Epidemiol. Biomarkers Prev., November 1, 2003; 12(11): 1213 - 1221. [Abstract] [Full Text]
|
|
|
|
|
|
K. D. Setchell and E. Lydeking-Olsen Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies Am. J. Clinical Nutrition, September 1, 2003; 78(3): 593S - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. R. Setchell, N. M. Brown, P. B. Desai, L. Zimmer-Nechimias, B. Wolfe, A. S. Jakate, V. Creutzinger, and J. E. Heubi Bioavailability, Disposition, and Dose-Response Effects of Soy Isoflavones When Consumed by Healthy Women at Physiologically Typical Dietary Intakes J. Nutr., April 1, 2003; 133(4): 1027 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Setchell, M. S Faughnan, T. Avades, L. Zimmer-Nechemias, N. M Brown, B. E Wolfe, W. T Brashear, P. Desai, M. F Oldfield, N. P Botting, et al. Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women Am. J. Clinical Nutrition, February 1, 2003; 77(2): 411 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. R. Setchell, N. M. Brown, and E. Lydeking-Olsen The Clinical Importance of the Metabolite Equol--A Clue to the Effectiveness of Soy and Its Isoflavones J. Nutr., December 1, 2002; 132(12): 3577 - 3584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Warren The Effects of Phytoestrogen Supplementation in Postmenopausal Women Reproductive Sciences, July 1, 2002; 9(4): 184 - 185. [PDF]
|
|
|
|
|
|
M. Messina, C. Gardner, and S. Barnes Gaining Insight into the Health Effects of Soy but a Long Way Still to Go: Commentary on the Fourth International Symposium on the Role of Soy in Preventing and Treating Chronic Disease J. Nutr., March 1, 2002; 132(3): 547S - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Messina and C. L. Loprinzi Soy for Breast Cancer Survivors: A Critical Review of the Literature J. Nutr., November 1, 2001; 131(11): 3095S - 3108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. R. Setchell Soy Isoflavones--Benefits and Risks from Nature's Selective Estrogen Receptor Modulators (SERMs) J. Am. Coll. Nutr., October 1, 2001; 20(90005): 354S - 362. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. G. Glazier and M. A. Bowman A Review of the Evidence for the Use of Phytoestrogens as a Replacement for Traditional Estrogen Replacement Therapy Arch Intern Med, May 14, 2001; 161(9): 1161 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Goodman-Gruen and D. Kritz-Silverstein Usual Dietary Isoflavone Intake Is Associated with Cardiovascular Disease Risk Factors in Postmenopausal Women J. Nutr., April 1, 2001; 131(4): 1202 - 1206. [Abstract] [Full Text]
|
|
|
|
|
|
K. D. R. Setchell, N. M. Brown, P. Desai, L. Zimmer-Nechemias, B. E. Wolfe, W. T. Brashear, A. S. Kirschner, A. Cassidy, and J. E. Heubi Bioavailability of Pure Isoflavones in Healthy Humans and Analysis of Commercial Soy Isoflavone Supplements J. Nutr., April 1, 2001; 131(4): 1362S - 1375. [Abstract] [Full Text]
|
|
|
|
|
|
K. E Wangen, A. M Duncan, X. Xu, and M. S Kurzer Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women Am. J. Clinical Nutrition, February 1, 2001; 73(2): 225 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Erdman Jr Soy Protein and Cardiovascular Disease : A Statement for Healthcare Professionals From the Nutrition Committee of the AHA Circulation, November 14, 2000; 102(20): 2555 - 2559. [Full Text] [PDF]
|
|
|
|
|
|
S. C. Ho, J. L. F. Woo, S. S. F. Leung, A. L. K. Sham, T. H. Lam, and E. D. Janus Intake of Soy Products Is Associated with Better Plasma Lipid Profiles in the Hong Kong Chinese Population J. Nutr., October 1, 2000; 130(10): 2590 - 2593. [Abstract] [Full Text]
|
|
|
|
 |
|
 L.-J. W. Lu, K. E. Anderson, J. J. Grady, F. Kohen, and M. Nagamani Decreased Ovarian Hormones during a Soya Diet: Implications for Breast Cancer Prevention Cancer Res., August 1, 2000; 60(15): 4112 - 4121. [Abstract] [Full Text]
|
|
|
|
|
|
B. E Merz-Demlow, A. M Duncan, K. E Wangen, X. Xu, T. P Carr, W. R Phipps, and M. S Kurzer Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women Am. J. Clinical Nutrition, June 1, 2000; 71(6): 1462 - 1469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Fernandez, T. A. Wilson, K. Conde, M. Vergara-Jimenez, and R. J. Nicolosi Hamsters and Guinea Pigs Differ in Their Plasma Lipoprotein Cholesterol Distribution when Fed Diets Varying in Animal Protein, Soluble Fiber, or Cholesterol Content J. Nutr., July 1, 1999; 129(7): 1323 - 1332. [Abstract] [Full Text]
|
|
|
|
|
|
C. L. Wells, R. P. Jechorek, K. M. Kinneberg, S. M. Debol, and S. L. Erlandsen The Isoflavone Genistein Inhibits Internalization of Enteric Bacteria by Cultured Caco-2 and HT-29 Enterocytes J. Nutr., March 1, 1999; 129(3): 634 - 640. [Abstract] [Full Text]
|
|
|
|
|
|
K. D. R. Setchell and A. Cassidy Dietary Isoflavones: Biological Effects and Relevance to Human Health J. Nutr., March 1, 1999; 129(3): 758 - 758. [Abstract] [Full Text]
|
|
