The Maltitol-induced Increase in Intestinal Calcium Transport Increases the Calcium Content and Breaking Force of Femoral Bone in Weanling Rats

Manuscript received 22 April 1998. Initial reviews completed 21 May 1998. Revision accepted 14 July 1998.

Toshinao Goda^*, , Kazuhiro Kishi^*, Ikuko Ezawa, and Sachiko Takase^*

^*  School of Food and Nutritional Sciences, The University of Shizuoka, Shizuoka 422-8526, Japan and   Department of Food and Nutrition, School of Home Economics, Japan Women's University, Tokyo 112, Japan

Maltitol is a disaccharide alcohol that is produced by hydrogenation of maltose and exhibits resistance to intestinal disaccharidases. We demonstrated previously that maltitol stimulated transepithelial diffusional calcium transfer in the ileum, accompanied by an elevation of intestinal calcium absorption as well as calcium retention in the body. In this study we examined whether the maltitol-induced increase in the diffusional transfer of intestinal calcium absorption leads to an alteration of the physical properties of bones in the weanling rats which exhibit the maximal level of intestinal active calcium absorption. Rat pups were removed from dams at 24 d of age and were fed the diets containing either maltose (control) or maltitol and a requisite amount of calcium (0.52%) for 21 d. Balance studies performed during the final 5-d period showed that maltitol-fed rats had greater calcium retention and calcium absorption. The breaking force of femoral bones was 13% greater in the rats fed the maltitol diet than in controls. The calcium content and dry weight of both femurs and tibias, as well as the bone mineral density of tibias, were elevated in the rats fed the maltitol diet. In a separate experiment, gastric intubation of maltitol-containing diet increased the serum calcium concentration in the portal vein at 2 and 4 h compared to controls. These results indicate that the maltitol-induced increase in the intestinal calcium absorption through paracellular pathway leads to enhancement of the calcium content and the breaking strength in the bone of weanling rats.

The Journal of Nutrition Vol. 128 No. 11 November 1998, pp. 2028-2031
Copyright ©1998 by the American Society for Nutritional Sciences

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