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A Low-Viscosity Soluble-Fiber Fruit Juice Supplement Fails to Lower Cholesterol in Hypercholesterolemic Men and Women

Manuscript received 26 March 1998. Initial reviews completed 9 June 1998. Revision accepted 4 August 1998.

Michael H. Davidson, Lynn D. Dugan, Jill Stocki, Mary R. Dicklin, Kevin C. Maki,, Frances Coletta*, Richard Cotter*, , Max McLeod*, and Kenneth Hoersten*

The Chicago Center for Clinical Research, Chicago, IL 60610, U.S. and * Gerber Products Company, Fremont, MI 49413, U.S.

This study was designed to determine whether a soluble dietary fiber supplement containing gum arabic and pectin in apple juice would lower serum lipids in 110 hypercholesterolemic men and women. Subjects were stabilized on an American Heart Association Phase I Diet for 8 wk. Those with elevated low density lipoprotein cholesterol levels, despite dietary modification, continued to follow the diet and were randomly assigned to receive 720 mL/d of apple juice containing 0 (control), 5, 9 or 15 g of gum arabic and pectin (4:1 ratio) for 12 wk, followed by a 6-wk apple juice-only washout phase. Serum lipid profiles, body weight and 3-day diet records were collected at 3-wk intervals. No significant differences among groups were observed in serum lipid responses during treatment or washout. During the treatment phase, mean serum total cholesterol and triglyceride concentrations increased by 3.5 and 28.5%, respectively (all groups combined, P < 0.0001). The high density lipoprotein cholesterol level did not change significantly from baseline in any group. During washout, mean total cholesterol concentration rose by an additional 2.4% (P < 0.05) compared with the value at the end of the treatment period, suggesting that the apple juice used to deliver the fiber supplement may have contributed to the adverse changes observed in the serum lipid profile. These findings do not support the hypothesized hypocholesterolemic effect of the gum arabic/pectin (4:1) mixture studied, but do underline the importance of selecting appropriate vehicles for delivery of dietary fiber mixtures.

Key words: hypercholesterolemia, water-soluble dietary fiber, viscosity, fructose, humans.

The Journal of Nutrition Vol. 128 No. 11 November 1998, pp. 1927-1932
Copyright ©1998 by the American Society for Nutritional Sciences






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Copyright © 1998 by American Society for Nutrition