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Manuscript received 9 April 1998. Initial reviews completed 27 May 1998. Revision accepted 7 July 1998.
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263
The article reviews the progress in basic research of selenium and cancer prevention during the past decade. Special emphasis is placed on the following four major areas of discussion: 1) chemical forms of selenium and anticarcinogenic activity; 2) selenium-enriched food; 3) in vitro effects of selenite vs. monomethylated selenium; and 4) aromatic selenium compounds. It is clear that basic research has contributed new knowledge to our understanding of selenium biochemistry, anticancer efficacy and regulation of cell growth. Some of this information could be ready for incorporation into the design of a second-generation selenium trial in humans.
Key words: selenium biochemistry, cancer prevention, animal models, cell growth regulation.
The Journal of Nutrition Vol. 128 No. 11 November 1998,
pp. 1845-1854
Copyright ©1998 by the American Society for Nutritional Sciences
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