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Dietary Xylitol Protects Against Weakening of Bone Biomechanical Properties in Ovariectomized Rats

Manuscript received 30 December 1997. Initial reviews completed 20 February 1998. Revision accepted 11 June 98.

Pauli T. Mattila*, , Martti J. Svanberg*, Pauli Pökkä*, and Matti L. E. Knuuttiladagger

* Institute of Dentistry, University of Oulu, 90220 Oulu, Finland and dagger  Oral and Maxillofacial Department, Oulu University Hospital, 90220 Oulu, Finland

The effects of dietary xylitol (xyl) on bone biomechanical properties in ovariectomized rats (ovx) were studied. Forty-two 3-mo-old female Wistar rats were divided into three groups of 14. Rats in two groups were ovariectomized, while those in the control group underwent a sham operation. All rats received a basal diet, and half of the ovx were given an additional 10 g/100 g dietary xyl supplementation. Three months later the rats were killed and their tibias, femurs and humeri were prepared. The tibias were used for analyses of bone density and trabecular bone volume (BV/TV) and for the three-point bending test. The femurs were used for the torsion test and for the loading test of the femoral neck. The humeri were used for analyses of bone ash weight and bone concentrations of calcium and phosphorus. Dietary xyl gave a significant protection against ovariectomy-caused decline of tibial stress in the three-point bending test, of femoral shear stress in the torsion test, and of stress of the femoral neck, without affecting bone elasticity values. Xyl restricted the ovariectomy-caused reduction in bone density, in bone ash weight and in concentrations of bone calcium and phosphorus. Furthermore, trabecular bone loss in ovx was significantly suppressed by dietary xyl. These results indicate that a 10% dietary supplementation of xyl in ovx has a protective effect against the weakening of bone biomechanical properties. This is related to greater BV/TV and maintained bone mineral content.

Key words: , bone biomechanics, dietary xylitol, rats, experimental osteoporosis, trabecular bone volume.

The Journal of Nutrition Vol. 128 No. 10 October 1998, pp. 1811-1814
Copyright ©1998 by the American Society for Nutritional Sciences




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