![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Manuscript received 20 February 1997. Initial reviews completed 25 April 1997. Revision accepted 2 September 1997.
, and
* Unité de Biochimie Toxicologique et Cancérologique, Department of Pharmaceutical Sciences, Université Catholique de Louvain, B1200 Brussels, Belgium; ORAFTI, B3300 Tienen, Belgium; and ** Microbiology Department, Institute of Food Research, Reading Laboratory, Earley Gate, Reading, U.K.
Research data on the bifidogenic effect of 
(2-1)fructans, which at present are commercialized in the U.S., Japan and Europe as food ingredients, are presented. These food ingredients originate from two different sources. Short-chain fructo-oligosaccharides are synthesized from sucrose and are composed of GFn [n (2-1) linked fructose moieties bound to a glucose molecule; 2 
n 4]. The longer chain length molecule inulin is extracted with hot water from chicory roots (Cichorium intybus) and is also composed of GFn molecules (with 2 < n < 60). Oligofructose is a partial hydrolysate of inulin and is composed of GFn and Fm molecules (n and m indicate the number of fructose moieties with 2 n, m 7). All types of (2-1)fructans are well fermented by intestinal bacteria. For a given chain length, there is no difference in fermentation rate between GFn- and Fm-type -fructans. In vitro fermentation of inulin revealed that molecules with a chain length (degree of polymerization or DP) > 10 are fermented on average half as quickly as molecules with a DP < 10. All (2
1)fructans are bifidogenic and classified as biobiotics.
The Journal of Nutrition Vol. 128 No. 1 January 1998,
pp. 11-19
Copyright ©1998 by the American Society for Nutritional Sciences
This article has been cited by other articles:
|
|
 |
|
  G. Bosch, W. F. Pellikaan, P. G. P. Rutten, A. F. B. van der Poel, M. W. A. Verstegen, and W. H. Hendriks Comparative in vitro fermentation activity in the canine distal gastrointestinal tract and fermentation kinetics of fiber sources J Anim Sci, November 1, 2008; 86(11): 2979 - 2989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Cloetens, V. De Preter, K. Swennen, W. F. Broekaert, C. M. Courtin, J. A. Delcour, P. Rutgeerts, and K. Verbeke Dose-Response Effect of Arabinoxylooligosaccharides on Gastrointestinal Motility and on Colonic Bacterial Metabolism in Healthy Volunteers J. Am. Coll. Nutr., August 1, 2008; 27(4): 512 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Roberfroid Inulin-Type Fructans: Functional Food Ingredients J. Nutr., November 1, 2007; 137(11): 2493S - 2502S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. M. Leenen and L. A. Dieleman Inulin and Oligofructose in Chronic Inflammatory Bowel Disease J. Nutr., November 1, 2007; 137(11): 2572S - 2575S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Tuohy Inulin-Type Fructans in Healthy Aging J. Nutr., November 1, 2007; 137(11): 2590S - 2593S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Roberfroid Prebiotics: The Concept Revisited J. Nutr., March 1, 2007; 137(3): 830S - 837S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Falony, A. Vlachou, K. Verbrugghe, and L. D. Vuyst Cross-Feeding between Bifidobacterium longum BB536 and Acetate-Converting, Butyrate-Producing Colon Bacteria during Growth on Oligofructose Appl. Envir. Microbiol., December 1, 2006; 72(12): 7835 - 7841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Vanhoutte, V. De Preter, E. De Brandt, K. Verbeke, J. Swings, and G. Huys Molecular Monitoring of the Fecal Microbiota of Healthy Human Subjects during Administration of Lactulose and Saccharomyces boulardii Appl. Envir. Microbiol., September 1, 2006; 72(9): 5990 - 5997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nakanishi, K. Murashima, H. Ohara, T. Suzuki, H. Hayashi, M. Sakamoto, T. Fukasawa, H. Kubota, A. Hosono, T. Kono, et al. Increase in Terminal Restriction Fragments of Bacteroidetes-Derived 16S rRNA Genes after Administration of Short-Chain Fructooligosaccharides Appl. Envir. Microbiol., September 1, 2006; 72(9): 6271 - 6276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Liong and N. P. Shah Effects of a Lactobacillus casei Synbiotic on Serum Lipoprotein, Intestinal Microflora, and Organic Acids in Rats J Dairy Sci, May 1, 2006; 89(5): 1390 - 1399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Van den Ende, S. Clerens, R. Vergauwen, D. Boogaerts, K. Le Roy, L. Arckens, and A. Van Laere Cloning and functional analysis of a high DP fructan:fructan 1-fructosyl transferase from Echinops ritro (Asteraceae): comparison of the native and recombinant enzymes J. Exp. Bot., March 1, 2006; 57(4): 775 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mueller, K. Saunier, C. Hanisch, E. Norin, L. Alm, T. Midtvedt, A. Cresci, S. Silvi, C. Orpianesi, M. C. Verdenelli, et al. Differences in Fecal Microbiota in Different European Study Populations in Relation to Age, Gender, and Country: a Cross-Sectional Study Appl. Envir. Microbiol., February 1, 2006; 72(2): 1027 - 1033. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Lopez-Huertas, B. Teucher, J. J Boza, A. Martinez-Ferez, G. Majsak-Newman, L. Baro, J. J Carrero, M. Gonzalez-Santiago, J. Fonolla, and S. Fairweather-Tait Absorption of calcium from milks enriched with fructo-oligosaccharides, caseinophosphopeptides, tricalcium phosphate, and milk solids Am. J. Clinical Nutrition, February 1, 2006; 83(2): 310 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Kien, M. Schmitz-Brown, T. Solley, D. Sun, and W. L. Frankel Increased Colonic Luminal Synthesis of Butyric Acid Is Associated with Lowered Colonic Cell Proliferation in Piglets J. Nutr., January 1, 2006; 136(1): 64 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Makras, G. Van Acker, and L. De Vuyst Lactobacillus paracasei subsp. paracasei 8700:2 Degrades Inulin-Type Fructans Exhibiting Different Degrees of Polymerization Appl. Envir. Microbiol., November 1, 2005; 71(11): 6531 - 6537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Tzortzis, A. K. Goulas, J. M. Gee, and G. R. Gibson A Novel Galactooligosaccharide Mixture Increases the Bifidobacterial Population Numbers in a Continuous In Vitro Fermentation System and in the Proximal Colonic Contents of Pigs In Vivo J. Nutr., July 1, 2005; 135(7): 1726 - 1731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Rastall Bacteria in the Gut: Friends and Foes and How to Alter the Balance J. Nutr., August 1, 2004; 134(8): 2022S - 2026S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Michiels, A. Van Laere, W. Van den Ende, and M. Tucker Expression analysis of a chicory fructan 1-exohydrolase gene reveals complex regulation by cold J. Exp. Bot., June 1, 2004; 55(401): 1325 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Van der Meulen, L. Avonts, and L. De Vuyst Short Fractions of Oligofructose Are Preferentially Metabolized by Bifidobacterium animalis DN-173 010 Appl. Envir. Microbiol., April 1, 2004; 70(4): 1923 - 1930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S J M Ten Bruggencate, I M J Bovee-Oudenhoven, M L G Lettink-Wissink, M B Katan, and R Van der Meer Dietary fructo-oligosaccharides and inulin decrease resistance of rats to salmonella: protective role of calcium Gut, April 1, 2004; 53(4): 530 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Van den Ende, S. Clerens, R. Vergauwen, L. Van Riet, A. Van Laere, M. Yoshida, and A. Kawakami Fructan 1-Exohydrolases. beta -(2,1)-Trimmers during Graminan Biosynthesis in Stems of Wheat? Purification, Characterization, Mass Mapping, and Cloning of Two Fructan 1-Exohydrolase Isoforms Plant Physiology, February 1, 2003; 131(2): 621 - 631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Femia, C. Luceri, P. Dolara, A. Giannini, A. Biggeri, M. Salvadori, Y. Clune, K. J. Collins, M. Paglierani, and G. Caderni Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats Carcinogenesis, November 1, 2002; 23(11): 1953 - 1960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Verghese, D. R. Rao, C. B. Chawan, and L. Shackelford Dietary Inulin Suppresses Azoxymethane-Induced Preneoplastic Aberrant Crypt Foci in Mature Fisher 344 Rats J. Nutr., September 1, 2002; 132(9): 2804 - 2808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Boehm, M Lidestri, P Casetta, J Jelinek, F Negretti, B Stahl, and A Marini Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2002; 86(3): F178 - F181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Buddington, J. B. Donahoo, and R. K. Buddington Dietary Oligofructose and Inulin Protect Mice from Enteric and Systemic Pathogens and Tumor Inducers J. Nutr., March 1, 2002; 132(3): 472 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.J. McBAIN and G.T. MACFARLANE Modulation of genotoxic enzyme activities by non-digestible oligosaccharide metabolism in in-vitro human gut bacterial ecosystems J. Med. Microbiol., September 1, 2001; 50(9): 833 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Van den Ende, A. Michiels, D. Van Wonterghem, S. P. Clerens, J. De Roover, and A. J. Van Laere Defoliation Induces Fructan 1-Exohydrolase II in Witloof Chicory Roots. Cloning and Purification of Two Isoforms, Fructan 1-Exohydrolase IIa and Fructan 1-Exohydrolase IIb. Mass Fingerprint of the Fructan 1-Exohydrolase II Enzymes Plant Physiology, July 1, 2001; 126(3): 1186 - 1195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B Roberfroid Prebiotics: preferential substrates for specific germs? Am. J. Clinical Nutrition, February 1, 2001; 73(2): 406S - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E Scholz-Ahrens, G. Schaafsma, E. G. van den Heuvel, and J. Schrezenmeir Effects of prebiotics on mineral metabolism Am. J. Clinical Nutrition, February 1, 2001; 73(2): 459S - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hughes and I.R. Rowland Stimulation of apoptosis by two prebiotic chicory fructans in the rat colon Carcinogenesis, January 1, 2001; 22(1): 43 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kaplan and R. W. Hutkins Fermentation of Fructooligosaccharides by Lactic Acid Bacteria and Bifidobacteria Appl. Envir. Microbiol., June 1, 2000; 66(6): 2682 - 2684. [Abstract] [Full Text]
|
|
|
|
|
|
M. B Roberfroid Prebiotics and probiotics: are they functional foods? Am. J. Clinical Nutrition, June 1, 2000; 71(6): 1682S - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Menne and N. Guggenbuhl Fn-type Chicory Inulin Hydrolysate Has a Prebiotic Effect in Humans J. Nutr., May 1, 2000; 130(5): 1197 - 1199. [Abstract] [Full Text]
|
|
|
|
|
|
M. B. Roberfroid Concepts in Functional Foods: The Case of Inulin and Oligofructose J. Nutr., July 1, 1999; 129(7): 1398 - 1398. [Abstract] [Full Text]
|
|
|
|
|
|
K. R. Niness Inulin and Oligofructose: What Are They? J. Nutr., July 1, 1999; 129(7): 1402 - 1402. [Abstract] [Full Text]
|
|
|
|
|
|
M. B. Roberfroid Caloric Value of Inulin and Oligofructose J. Nutr., July 1, 1999; 129(7): 1436 - 1436. [Abstract] [Full Text]
|
|
|
|
|
|
J. O. Hunter, Q. Tuffnell, and A. J. Lee Controlled Trial of Oligofructose in the Management of Irritable Bowel Syndrome J. Nutr., July 1, 1999; 129(7): 1451 - 1451. [Abstract] [Full Text]
|
|
