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The Journal of Nutrition Vol. 127 No. 8 August 1997, pp. 1589S-1608S
Copyright ©1997 by the American Society for Nutritional Sciences

Olestra's Effect on the Status of Vitamins A, D and E in the Pig Can Be Offset by Increasing Dietary Levels of These Vitamins

Dale A. Cooper, Delia A. Berry, Michaelle B. Jones, Anthony L. Kiorpes*, and John C. Peters

The Procter & Gamble Company, Winton Hill Technical Center, Cincinnati, OH 45224 and * Hazleton-Wisconsin, Inc., Madison, WI 53707

Groups of weanling pigs (5 castrated males, 5 females per group) were fed purified diets containing the NRC's requirements for nutrients and 0, 1.1, 4.4 or 7.7% olestra for 12 wk. Graded concentrations of vitamins A, D2 and E were added at each olestra concentration. The primary purpose of the study was to establish relationships between dietary concentration of olestra and the amounts of vitamins A, D2 and E needed to restore tissue concentrations of these vitamins to control concentrations. A secondary purpose was to confirm that olestra does not affect the status of vitamin K or water-soluble nutrients. Liver concentrations of vitamins A, E and B12, iron and zinc and bone concentrations of ash, zinc, calcium and phosphorus, were measured in a group of pigs killed at the start of the study and in all pigs killed at wk 12. Growth, feed efficiency, hematology, clinical chemistry, blood concentrations of retinol, alpha -tocopherol, 25-hydroxyergocalciferol, 25-hydroxycholecalciferol, 1,25-dihydroxyvitamin D, folate, iron, total iron-binding capacity, zinc and calcium and adipose concentration of vitamin E were measured at 4-wk intervals. Prothrombin time was measured weekly for the control and 7.7% olestra groups, monthly for others. Relationships derived from measured tissue concentrations of vitamins A and E showed that constant amounts of the vitamins were required per unit mass of olestra in the diet to restore tissue concentrations to control values. Such a relationship could not be determined for vitamin D because exposure of the pigs to UV light resulted in an apparent interaction between vitamin D2 and vitamin D3. Olestra did not affect growth, digestible feed efficiency, vitamin K status or the status of the water-soluble micronutrients, in agreement with other studies in the pig.

Key words: pigs, olestra, fat-soluble vitamins, minerals, folate, vitamin B12.






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Copyright © 1997 by American Society for Nutrition