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The Journal of Nutrition Vol. 127 No. 8 August 1997, pp. 1519-1526
Copyright ©1997 by the American Society for Nutritional Sciences

Evidence for Histamine Involvement in the Effect of Histidine Loads on Food and Water Intake in Rats

Manuscript received 10 July 1996. Initial reviews completed 3 October 1996. Revision accepted 11 April 1997.

Peyman Vaziri, Karen Dang, and G. Harvey Anderson

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto M5S 3E2, Canada

We examined the hypothesis that histidine is a regulator of short-term food and water intake in rats and that this control is through histidine's action as a precursor for histamine. The primary objectives were to measure food and water intake after histidine monohydrochloride monohydrate (His-HCl) given by intragastric (IG) and intraperitoneal (IP) routes of administration and to measure feeding and drinking responses to histidine when given after blockade of the histaminergic pathway by chlorpheniramine (CPA) and alpha -fluoromethylhistidine (FMH). Eight experiments were conducted using a back-to-back design. Rats were given treatment by IP or IG administration, and food and water intake was measured during time periods of 0-1, 1-2, 2-3 and 3-14 h. Histidine consistently reduced food intake with the sensitivity to IP much greater than to the IG route. The effect of histidine given by IP or IG on water intake was similar, generally causing an increase at least in the first hour. Histidine's action was not accounted for by its energy, pH or nitrogen content. Because FMH, which blocks the enzyme converting histidine to histamine, partially reversed the effect of histidine on food and water intake, these results support the hypothesis that histidine regulates food and water intake, at least in part, through its precursor control of histamine.

Key words: histidine, histamine, alpha -fluoromethylhistidine, food intake, rats.




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N. Torres, L. Martínez, G. Alemán, H. Bourges, and A. R. Tovar
Histidase Expression Is Regulated by Dietary Protein at the Pretranslational Level in Rat Liver
J. Nutr., May 1, 1998; 128(5): 818 - 824.
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