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The Journal of Nutrition Vol. 127 No. 6 June 1997, pp. 1229-1242
Copyright ©1997 by the American Society for Nutritional Sciences

Description of a Model Integrating Protein and Energy Metabolism in Preruminant Calves

Manuscript received 30 April 1996. Initial reviews completed 18 June 1996. Revision accepted 21 January 1997.

Walter J. J. Gerrits*, , Jan Dijkstradagger , and James Francedagger

*  Wageningen Institute of Animal Sciences, Wageningen Agricultural University, 6700 AH, Wageningen, The Netherlands and dagger   Institute of Grassland and Environmental Research, North Wyke, Okehampton, EX20 2SB, UK

This paper describes the development of a mechanistic model integrating protein and energy metabolism in preruminant calves of 80-240 kg live weight. The objectives of the model are to gain insight into the partitioning of nutrients in the body of growing calves and to provide a tool for the development of feeding strategies for calves in this weight range. The model simulates the partitioning of nutrients from ingestion through intermediary metabolism to growth, consisting of accretions of protein, fat, ash and water. The model contains 10 state variables, comprising fatty acids, glucose, acetyl-CoA and amino acids as metabolite pools, and fat, ash and protein in muscle, hide, bone and viscera as body constituent pools. Turnover of protein and fat is represented. The model also includes a routine to check possible dietary amino acid imbalance and can be used to predict amino acid requirements on a theoretical basis. The model is based on two experiments, specifically designed for this purpose. Simulations of protein and fat accretion rates over a wide range of nutrient input suggest that the model is sound. It can be used as a research tool and for the development of feeding strategies for preruminant calves.

Key words: veal calves, computer simulation, mathematical model, protein metabolism, energy metabolism.




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Copyright © 1997 by American Society for Nutrition