![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Manuscript received 6 August 1996. Initial reviews completed 8 October 1996. Revision accepted 17 February 1997.
,
Department of Food Science, Lipid Chemistry and Metabolism Laboratory, Purdue University, West Lafayette, IN 47907-1160; * USDA, Growth Biology Laboratory, Livestock and Poultry Institute, Beltsville, MD 20705; ZymoGenetics, Inc., Seattle, WA 98105; ** Department of Food Science and Human Nutrition, Colorado State University, Ft. Collins, CO 80523; and Department of Anatomy, Indiana University Medical Center, Indianapolis, IN 46202
This study examined the effects of dietary fat on the fatty acid composition of liver and bone, and on the concentration of insulin-like growth factor-I (IGF-I) in liver and bone, as well as the relationship of these factors to bone metabolism. Day-old male broiler chicks were given a semipurified diet containing one of four lipid sources: soybean oil (SBO), butter + corn oil (BC), margarine + corn oil (MAC), or menhaden oil + corn oil (MEC) at 70 g/kg of the diet. At 21 and 42 d of age, chicks fed MEC had the highest concentration of (n-3) fatty acids [20:5(n-3), 22:5(n-3) and 22:6(n-3)] in polar and neutral lipids of cortical bone but the lowest amount of 20:4(n-6) in polar lipids. Diets containing t-18:1 fatty acids (MAC and BC) resulted in t18:1 accumulation in bone and liver. Bone IGF-I concentration increased from 21 to 42 d in chicks given the SBO and BC diets. Tibial periosteal bone formation rate (BFR) was higher in chicks given BC compared with those consuming SBO and MEC at 21 d. The higher BFR and concentrations of hexosamine in serum and IGF-I in cartilage, but lower 20:4(n-6) content in bone polar lipids in chicks given BC compared with those given SBO suggest that BC optimized bone formation by altering the production of bone growth factors. A second study confirmed that dietary butter fat lowered ex vivo prostaglandin E2 production and increased trabecular BFR in chick tibia. These studies showed that dietary fat altered BFR perhaps by controlling the production of local regulatory factors in bone.
Key words: lipids, bone, prostaglandin E2, insulin-like growth factor-I, chicks.
This article has been cited by other articles:
|
|
 |
|
  H. T. Baird, D. L. Eggett, and S. Fullmer Varying Ratios of Omega-6:Omega-3 Fatty Acids on the Pre-and Postmortem Bone Mineral Density, Bone Ash, and Bone Breaking Strength of Laying Chickens Poult. Sci., February 1, 2008; 87(2): 323 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. H. Lin and N. Salem Jr. Whole body distribution of deuterated linoleic and {alpha}-linolenic acids and their metabolites in the rat J. Lipid Res., December 1, 2007; 48(12): 2709 - 2724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Platt, L. G. Rao, and A. El-Sohemy Isomer-Specific Effects of Conjugated Linoleic Acid on Mineralized Bone Nodule Formation from Human Osteoblast-LikeCells Experimental Biology and Medicine, February 1, 2007; 232(2): 246 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Dibner, J. D. Richards, M. L. Kitchell, and M. A. Quiroz Metabolic Challenges and Early Bone Development J. Appl. Poult. Res., January 1, 2007; 16(1): 126 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Burr, C. G. Taylor, and H. A. Weiler Dietary Conjugated Linoleic Acid Does Not Adversely Affect Bone Mass in Obese fa/fa or Lean Zucker Rats. Experimental Biology and Medicine, November 1, 2006; 231(10): 1602 - 1609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Rahman, A. Bhattacharya, and G. Fernandes Conjugated linoleic acid inhibits osteoclast differentiation of RAW264.7 cells by modulating RANKL signaling J. Lipid Res., August 1, 2006; 47(8): 1739 - 1748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Brownbill, M. Petrosian, and J. Z. Ilich Association between Dietary Conjugated Linoleic Acid and Bone Mineral Density in Postmenopausal Women J. Am. Coll. Nutr., June 1, 2005; 24(3): 177 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Mollard, M. E. Gillam, T. M. Wood, C. G. Taylor, and H. A. Weiler (n-3) Fatty Acids Reduce the Release of Prostaglandin E2 from Bone but Do Not Affect Bone Mass in Obese (fa/fa) and Lean Zucker Rats J. Nutr., March 1, 2005; 135(3): 499 - 504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Mollard, H. R. Kovacs, S. C. Fitzpatrick-Wong, and H. A. Weiler Low Levels of Dietary Arachidonic and Docosahexaenoic Acids Improve Bone Mass in Neonatal Piglets, but Higher Levels Provide No Benefit J. Nutr., March 1, 2005; 135(3): 505 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Reinwald, Y. Li, T. Moriguchi, N. Salem Jr., and B. A. Watkins Repletion with (n-3) Fatty Acids Reverses Bone Structural Deficits in (n-3)-Deficient Rats J. Nutr., February 1, 2004; 134(2): 388 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L Blanaru, J. R Kohut, S. C Fitzpatrick-Wong, and H. A Weiler Dose response of bone mass to dietary arachidonic acid in piglets fed cow milk-based formula Am. J. Clinical Nutrition, January 1, 2004; 79(1): 139 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Weiler and S. C. Fitzpatrick-Wong Modulation of Essential (n-6):(n-3) Fatty Acid Ratios Alters Fatty Acid Status but Not Bone Mass in Piglets J. Nutr., September 1, 2002; 132(9): 2667 - 2672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Watkins, Y. Li, and M. F. Seifert Nutraceutical Fatty Acids as Biochemical and Molecular Modulators of Skeletal Biology J. Am. Coll. Nutr., October 1, 2001; 20(90005): 410S - 416. [Abstract] [Full Text]
|
|
|
|
|
|
B. A. Watkins, Y. Li, H. E. Lippman, and M. F. Seifert Omega-3 Polyunsaturated Fatty Acids and Skeletal Health Experimental Biology and Medicine, June 1, 2001; 226(6): 485 - 497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Watkins, Y. Li, K. G. D. Allen, W. E. Hoffmann, and M. F. Seifert Dietary Ratio of (n-6)/(n-3) Polyunsaturated Fatty Acids Alters the Fatty Acid Composition of Bone Compartments and Biomarkers of Bone Formation in Rats J. Nutr., September 1, 2000; 130(9): 2274 - 2284. [Abstract] [Full Text]
|
|
|
|
|
|
B. A. Watkins and M. F. Seifert Conjugated Linoleic Acid and Bone Biology J. Am. Coll. Nutr., August 1, 2000; 19(4): 478S - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Hankenson, B. A. Watkins, I. A. Schoenlein, K. G. D. Allen, and J. J. Turek Omega-3 Fatty Acids Enhance Ligament Fibroblast Collagen Formation in Association with Changes in Interleukin-6 Production Experimental Biology and Medicine, January 1, 2000; 223(1): 88 - 95. [Abstract] [Full Text]
|
|
|
|
|
|
S. M Innis and D J. King trans Fatty acids in human milk are inversely associated with concentrations of essential all-cis n-6 and n-3 fatty acids and determine trans, but not n-6 and n-3, fatty acids in plasma lipids of breast-fed infants Am. J. Clinical Nutrition, September 1, 1999; 70(3): 383 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Hayek, S. N. Han, D. Wu, B. A. Watkins, M. Meydani, J. L. Dorsey, D. E. Smith, and S. N. Meydani Dietary Conjugated Linoleic Acid Influences the Immune Response of Young and Old C57BL/6NCrlBR Mice. J. Nutr., January 1, 1999; 129(1): 32 - 38. [Abstract] [Full Text] [PDF]
|
|
