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The Journal of Nutrition Vol. 127 No. 5 May 1997, pp. 826S-829S
Copyright ©1997 by the American Society for Nutritional Sciences

Effects of Diet on Urinary Bladder Carcinogenesis and Cancer Prevention

Samuel M. Cohen, Tsuneo Masui, Emily M. Garland, and Lora L. Arnold

Department of Pathology and Microbiology and the Eppley Institute for Research on Cancer, University of Nebraska Medical Center, Omaha, NE 68198

Urine plays a major role in bladder carcinogenesis, acting as a transport mechanism for carcinogens, containing several growth factors stimulating cell proliferation, and indirectly affecting chemicals by alterations in concentrations of normal urinary components such as electrolytes, water and proteins. These latter effects are greatly modified by diet composition and consumption and also by water consumption. Several examples of these effects are presented.

Key words: urine, calculi, saccharin, sodium salts.




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