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The Journal of Nutrition Vol. 127 No. 5 May 1997, pp. 1014S-1016S
Copyright ©1997 by the American Society for Nutritional Sciences

Inflammatory and Hormonal Mediators of Cachexia

Ronenn Roubenoff

Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111

Body composition is a reflection of the metabolic state of the organism. However, because the time course of change in body composition is slower than that of metabolic processes, measurement of body composition offers a unique way of assessing the organism's physiologic status. The hormonal and immune mediators that control metabolism, and thus body composition, can be divided into three categories: day-to-day regulators (insulin and glucagon), life cycle-related hormones (estrogens and androgens, growth hormone, prolactin, thyroid hormones, catecholamines, corticosteroids) and immunologic mediators (the cytokines interleukin-1, tumor necrosis factor, and interleukin-6). Although the cytokines can clearly drive metabolism and thus body composition in various illnesses, it is not yet clear whether they also play a homeostatic role in the age-related changes in body composition that we now call sarcopenia.

Key words: hormones, immune system, aging, body composition.




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Copyright © 1997 by American Society for Nutrition