![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Manuscript received 22 December 1995. Initial reviews completed 19 February 1996. Revision accepted 5 August 1996.
Division of Nutritional Sciences, Cornell University, Ithaca, NY, 14853
Rats made obese by cafeteria feeding have poor reproductive outcomes. To investigate this phenomenon in animals fed a more nutritionally adequate diet, female rats were fed either a high fat (HF) (modified AIN-76ATM, 35 g fat/100 g diet) or a control (C) (AIN-76ATM, 5 g fat/100 g diet) diet, beginning at 27 d of age. To assess reproductive performance, rats were studied at d 0, 5 and 18 of pregnancy and on d 3 of lactation. Pregnancy rates were significantly (P < 0.001) lower in the high fat-fed rats than in the control-fed rats (56.4 and 89.1%, respectively). There was no difference between groups in total pregnancy weight gain or the proportion of weight gained during pregnancy that was retained by the dam. High fat-fed dams tended to gain weight more rapidly early in gestation than control-fed dams and then less rapidly than control-fed dams during the last week of gestation. Litter number and pup weight at birth did not differ between groups, but of high fat-fed pups had significantly higher (P < 0.04) mortality rates than pups of control-fed dams (16.5 and 7.7%, respectively) over the first 3 d of life. Control-fed dams experienced the expected reduction (P < 0.05) in plasma insulin concentrations between the end of pregnancy and early lactation, but high fat-fed dams did not. Thus, physiological mechanisms controlling distribution of metabolic fuels may not be functioning properly in high fat-fed dams. Therefore, consuming a high fat diet reduces a rat's capacity to conceive and ability to maintain her litter during the perinatal period.
Key words: obesity, overnutrition, pregnancy, rats.
This article has been cited by other articles:
|
|
 |
|
  G. J. Howie, D. M. Sloboda, T. Kamal, and M. H. Vickers Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet J. Physiol., February 15, 2009; 587(4): 905 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L Baker, K. F Michaelsen, T. I. Sorensen, and K. M Rasmussen High prepregnant body mass index is associated with early termination of full and any breastfeeding in Danish women Am. J. Clinical Nutrition, August 1, 2007; 86(2): 404 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. G. Irani, A. A. Dunn-Meynell, and B. E. Levin Altered Hypothalamic Leptin, Insulin, and Melanocortin Binding Associated with Moderate-Fat Diet and Predisposition to Obesity Endocrinology, January 1, 2007; 148(1): 310 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Hilson, K. M. Rasmussen, and C. L. Kjolhede Excessive Weight Gain during Pregnancy Is Associated with Earlier Termination of Breast-Feeding among White Women J. Nutr., January 1, 2006; 136(1): 140 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Clegg, S. C. Benoit, J. A. Reed, S. C. Woods, A. Dunn-Meynell, and B. E. Levin Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R981 - R986. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Rasmussen and C. L. Kjolhede Prepregnant Overweight and Obesity Diminish the Prolactin Response to Suckling in the First Week Postpartum Pediatrics, May 1, 2004; 113(5): e465 - e471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Hilson, K. M. Rasmussen, and C. L. Kjolhede High Prepregnant Body Mass Index is Associated With Poor Lactation Outcomes Among White, Rural Women Independent of Psychosocial and Demographic Correlates J Hum Lact, February 1, 2004; 20(1): 18 - 29. [Abstract] [PDF]
|
|
|
|
|
|
K. G. Dewey, L. A. Nommsen-Rivers, M. J. Heinig, and R. J. Cohen Risk Factors for Suboptimal Infant Breastfeeding Behavior, Delayed Onset of Lactation, and Excess Neonatal Weight Loss Pediatrics, September 1, 2003; 112(3): 607 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Rasmussen, J. A. Hilson, and C. L. Kjolhede Obesity May Impair Lactogenesis II J. Nutr., November 1, 2001; 131(11): 3009S - 3011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T Gerber, K. Holemans, I. O'Brien-Coker, A. I Mallet, R. van Bree, F A. Van Assche, and L. Poston Cholesterol-independent endothelial dysfunction in virgin and pregnant rats fed a diet high in saturated fat J. Physiol., June 1, 1999; 517(2): 607 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Koukkou, P. Ghosh, C. Lowy, and L. Poston Offspring of Normal and Diabetic Rats Fed Saturated Fat in Pregnancy Demonstrate Vascular Dysfunction Circulation, December 22, 1998; 98(25): 2899 - 2904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Rasmussen Effects of Under- and Overnutrition on Lactation in Laboratory Rats J. Nutr., February 1, 1998; 128(2): 390 - 390. [Abstract] [Full Text]
|
|
|
|
|
|
G. Frühbeck Leptin Involvement in Reproductive Performance J. Nutr., August 1, 1997; 127(8): 1533 - 1533. [Full Text]
|
|
