The Journal of Nutrition Vol. 127 No. 1 January 1997, pp. 153-157
Copyright ©1997 by the American Society for Nutritional Sciences

Lipid Metabolism Is Altered by Nebacitin in Rats Fed Cooked-Stored Polished Rice as the Only Dietary Carbohydrate with or without Exogenous Cholesterol

Manuscript received 7 July 1995. Initial reviews completed 23 October 1995. Revision accepted 24 September 1996.

School of Nutrition and Health Science, Taipei Medical College, Taipei 10502, Taiwan

Male adult Wistar rats were randomly divided into four groups in a 2 × 2 factorial design and were fed diets containing cooked-stored polished rice (CSPR), with and without 0.7 g/100 g of Nebacitin [bacitracin-neomycin sulfate (2:1, wt/wt)] and with and without 1 g cholesterol/100 g diet. The CSPR diet contained 1.87 g resistant starch/100 g. After 4 wk, arterial blood and liver were collected. Feces were collected during the last 7 d. Rats fed the diet with Nebacitin and cholesterol had higher serum total cholesterol than the rats fed diets without cholesterol. Serum triglyceride concentration was greater in rats fed Nebacitin, regardless of dietary cholesterol concentration. Rats fed the diet with Nebacitin and cholesterol had higher serum LDL cholesterol concentration and liver total cholesterol concentration than rats fed the other three diets. Rats fed the CSPR diet with Nebacitin both with and without cholesterol had a higher fecal resistant starch concentration and excretion and lower serum short-chain fatty acid concentration than rats fed the diets without Nebacitin. Hepatic cholesterol concentration was greater in rats fed Nebacitin only when the diet also contained cholesterol. Therefore, dietary Nebacitin alters lipid metabolism in rats, and some effects are most pronounced in those also fed cholesterol.

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