![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Manuscript received 17 May 1996. Initial reviews completed 12 July 1996. Revision accepted 16 September 1996.
Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801 and * Ross Products Division, Abbott Laboratories, Columbus, OH 43219
Certain indigestible oligosaccharides may benefit gastrointestinal tract health via fermentation and proliferation of desirable bacterial species. The purpose of this study was to elucidate effects of selected oligosaccharides on cecal and fecal short-chain fatty acid (SCFA) concentration, pH, total large bowel wet weight and wall weight, and gut microbiota levels in rats. Fifty male Sprague-Dawley rats were randomly assigned to one of five treatments: 1) control diet; 2) control diet + 5% microcrystalline cellulose (5% CC); 3) control diet + 5% CC + 6% fructooligosaccharides; 4) control diet + 5% CC + 6% oligofructose; or 5) control diet + 5% CC + 6% xylooligosaccharides. The control diet consisted of (dry matter basis) 20% protein, 65% carbohydrate, 10.5% fat, vitamin and mineral mixes. The duration of the study was 14 d. The oligofructose- and fructooligosaccharide-containing diets resulted in higher cecal butyrate concentrations compared with the control, cellulose and xylooligosaccharide diets. Generally, total cecal SCFA pools were higher while pH was lower from ingesting oligosaccharide-containing diets compared with control or cellulose diets. Cecal total weight and wall weight were higher from oligosaccharide consumption, whereas colonic total wet weight was higher for rats consuming xylooligosaccharides compared with other treatments; colon wall weight was unaffected by treatments. Cecal bifidobacteria and total anaerobes were higher whereas total aerobes were lower in rats fed oligosaccharide diets compared with those fed the control diet. Cecal lactobacilli levels were unaffected by treatment. Dietary incorporation of fermentable, indigestible oligosaccharides, by providing SCFA, lowering pH, and increasing bifidobacteria, may be beneficial in improving gastrointestinal health.
Key words: oligosaccharides, short-chain fatty acids, bifidobacteria, rats.
This article has been cited by other articles:
|
|
 |
|
  K. Yasuda, H. D. Dawson, E. V. Wasmuth, C. A. Roneker, C. Chen, J. F. Urban, R. M. Welch, D. D. Miller, and X. G. Lei Supplemental Dietary Inulin Influences Expression of Iron and Inflammation Related Genes in Young Pigs J. Nutr., November 1, 2009; 139(11): 2018 - 2023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Jankowski, J. Juskiewicz, K. Gulewicz, A. Lecewicz, B. A. Slominski, and Z. Zdunczyk The effect of diets containing soybean meal, soybean protein concentrate, and soybean protein isolate of different oligosaccharide content on growth performance and gut function of young turkeys Poult. Sci., October 1, 2009; 88(10): 2132 - 2140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Falony, A. Verschaeren, F. De Bruycker, V. De Preter, K. Verbeke, F. Leroy, and L. De Vuyst In Vitro Kinetics of Prebiotic Inulin-Type Fructan Fermentation by Butyrate-Producing Colon Bacteria: Implementation of Online Gas Chromatography for Quantitative Analysis of Carbon Dioxide and Hydrogen Gas Production Appl. Envir. Microbiol., September 15, 2009; 75(18): 5884 - 5892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Van Craeyveld, K. Swennen, E. Dornez, T. Van de Wiele, M. Marzorati, W. Verstraete, Y. Delaedt, O. Onagbesan, E. Decuypere, J. Buyse, et al. Structurally Different Wheat-Derived Arabinoxylooligosaccharides Have Different Prebiotic and Fermentation Properties in Rats J. Nutr., December 1, 2008; 138(12): 2348 - 2355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Swyers, A. O. Burk, T. G. Hartsock, E. M. Ungerfeld, and J. L. Shelton Effects of direct-fed microbial supplementation on digestibility and fermentation end-products in horses fed low- and high-starch concentrates J Anim Sci, October 1, 2008; 86(10): 2596 - 2608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Biggs, C. M. Parsons, and G. C. Fahey The Effects of Several Oligosaccharides on Growth Performance, Nutrient Digestibilities, and Cecal Microbial Populations in Young Chicks Poult. Sci., November 1, 2007; 86(11): 2327 - 2336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lagaert, S. Van Campenhout, A. Pollet, T. M. Bourgois, J. A. Delcour, C. M. Courtin, and G. Volckaert Recombinant Expression and Characterization of a Reducing-End Xylose-Releasing Exo-Oligoxylanase from Bifidobacterium adolescentis Appl. Envir. Microbiol., August 15, 2007; 73(16): 5374 - 5377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Roberfroid Prebiotics: The Concept Revisited J. Nutr., March 1, 2007; 137(3): 830S - 837S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Falony, A. Vlachou, K. Verbrugghe, and L. D. Vuyst Cross-Feeding between Bifidobacterium longum BB536 and Acetate-Converting, Butyrate-Producing Colon Bacteria during Growth on Oligofructose Appl. Envir. Microbiol., December 1, 2006; 72(12): 7835 - 7841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yasuda, K. R. Roneker, D. D. Miller, R. M. Welch, and X. G. Lei Supplemental Dietary Inulin Affects the Bioavailability of Iron in Corn and Soybean Meal to Young Pigs J. Nutr., December 1, 2006; 136(12): 3033 - 3038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Lesniewska, I. Rowland, P. D. Cani, A. M. Neyrinck, N. M. Delzenne, and P. J. Naughton Effect on Components of the Intestinal Microflora and Plasma Neuropeptide Levels of Feeding Lactobacillus delbrueckii, Bifidobacterium lactis, and Inulin to Adult and Elderly Rats. Appl. Envir. Microbiol., October 1, 2006; 72(10): 6533 - 6538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Loh, M. Eberhard, R. M. Brunner, U. Hennig, S. Kuhla, B. Kleessen, and C. C. Metges Inulin Alters the Intestinal Microbiota and Short-Chain Fatty Acid Concentrations in Growing Pigs Regardless of Their Basal Diet J. Nutr., May 1, 2006; 136(5): 1198 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. He, M. G. Priebe, H. J.M. Harmsen, F. Stellaard, X. Sun, G. W. Welling, and R. J. Vonk Colonic Fermentation May Play a Role in Lactose Intolerance in Humans J. Nutr., January 1, 2006; 136(1): 58 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V Lesniewska, I Rowland, H. N Laerke, G Grant, and P. J Naughton Relationship between dietary-induced changes in intestinal commensal microflora and duodenojejunal myoelectric activity monitored by radiotelemetry in the rat in vivo Exp Physiol, January 1, 2006; 91(1): 229 - 237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Berg, C. J. Fu, J. H. Porter, and M. S. Kerley Fructooligosaccharide supplementation in the yearling horse: Effects on fecal pH, microbial content, and volatile fatty acid concentrations J Anim Sci, July 1, 2005; 83(7): 1549 - 1553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. M. Ten Bruggencate, I. M. J. Bovee-Oudenhoven, M. L. G. Lettink-Wissink, and R. Van der Meer Dietary Fructooligosaccharides Increase Intestinal Permeability in Rats J. Nutr., April 1, 2005; 135(4): 837 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-K. Hsu, J.-W. Liao, Y.-C. Chung, C.-P. Hsieh, and Y.-C. Chan Xylooligosaccharides and Fructooligosaccharides Affect the Intestinal Microbiota and Precancerous Colonic Lesion Development in Rats J. Nutr., June 1, 2004; 134(6): 1523 - 1528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S J M Ten Bruggencate, I M J Bovee-Oudenhoven, M L G Lettink-Wissink, M B Katan, and R Van der Meer Dietary fructo-oligosaccharides and inulin decrease resistance of rats to salmonella: protective role of calcium Gut, April 1, 2004; 53(4): 530 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. M. Ten Bruggencate, I. M. J. Bovee-Oudenhoven, M. L. G. Lettink-Wissink, and R. Van der Meer Dietary Fructo-Oligosaccharides Dose-Dependently Increase Translocation of Salmonella in Rats J. Nutr., July 1, 2003; 133(7): 2313 - 2318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Busserolles, E. Gueux, E. Rock, C. Demigne, A. Mazur, and Y. Rayssiguier Oligofructose Protects against the Hypertriglyceridemic and Pro-oxidative Effects of a High Fructose Diet in Rats J. Nutr., June 1, 2003; 133(6): 1903 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Swanson, C. M. Grieshop, E. A. Flickinger, L. L. Bauer, J. Chow, B. W. Wolf, K. A. Garleb, and G. C. Fahey Jr Fructooligosaccharides and Lactobacillus acidophilus Modify Gut Microbial Populations, Total Tract Nutrient Digestibilities and Fecal Protein Catabolite Concentrations in Healthy Adult Dogs J. Nutr., December 1, 2002; 132(12): 3721 - 3731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. A. Apajalahti, H. Kettunen, A. Kettunen, W. E. Holben, P. H. Nurminen, N. Rautonen, and M. Mutanen Culture-Independent Microbial Community Analysis Reveals that Inulin in the Diet Primarily Affects Previously Unknown Bacteria in the Mouse Cecum Appl. Envir. Microbiol., October 1, 2002; 68(10): 4986 - 4995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Verghese, D. R. Rao, C. B. Chawan, and L. Shackelford Dietary Inulin Suppresses Azoxymethane-Induced Preneoplastic Aberrant Crypt Foci in Mature Fisher 344 Rats J. Nutr., September 1, 2002; 132(9): 2804 - 2808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Verghese, D. R. Rao, C. B. Chawan, L. L. Williams, and L. Shackelford Dietary Inulin Suppresses Azoxymethane-Induced Aberrant Crypt Foci and Colon Tumors at the Promotion Stage in Young Fisher 344 Rats J. Nutr., September 1, 2002; 132(9): 2809 - 2813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsukahara, H. Koyama, M. Okada, and K. Ushida Stimulation of Butyrate Production by Gluconic Acid in Batch Culture of Pig Cecal Digesta and Identification of Butyrate-Producing Bacteria J. Nutr., August 1, 2002; 132(8): 2229 - 2234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Swanson, C. M. Grieshop, E. A. Flickinger, L. L. Bauer, H.-P. Healy, K. A. Dawson, N. R. Merchen, and G. C. Fahey Jr Supplemental Fructooligosaccharides and Mannanoligosaccharides Influence Immune Function, Ileal and Total Tract Nutrient Digestibilities, Microbial Populations and Concentrations of Protein Catabolites in the Large Bowel of Dogs J. Nutr., May 1, 2002; 132(5): 980 - 989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Buddington, J. B. Donahoo, and R. K. Buddington Dietary Oligofructose and Inulin Protect Mice from Enteric and Systemic Pathogens and Tumor Inducers J. Nutr., March 1, 2002; 132(3): 472 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kimura, Y. Nagata, C. W. Bryant, and R. K. Buddington Nondigestible Oligosaccharides Do Not Increase Accumulation of Lipid Soluble Environmental Contaminants by Mice J. Nutr., January 1, 2002; 132(1): 80 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Topping and P. M. Clifton Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides Physiol Rev, July 1, 2001; 81(3): 1031 - 1064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Wollowski, G. Rechkemmer, and B. L Pool-Zobel Protective role of probiotics and prebiotics in colon cancer Am. J. Clinical Nutrition, February 1, 2001; 73(2): 451S - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E Scholz-Ahrens, G. Schaafsma, E. G. van den Heuvel, and J. Schrezenmeir Effects of prebiotics on mineral metabolism Am. J. Clinical Nutrition, February 1, 2001; 73(2): 459S - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Hughes and I.R. Rowland Stimulation of apoptosis by two prebiotic chicory fructans in the rat colon Carcinogenesis, January 1, 2001; 22(1): 43 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P Perrin, F Pierre, Y Patry, M Champ, M Berreur, G Pradal, F Bornet, K Meflah, and J Menanteau Only fibres promoting a stable butyrate producing colonic ecosystem decrease the rate of aberrant crypt foci in rats Gut, January 1, 2001; 48(1): 53 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Delzenne, N. Kok, P. Deloyer, and G. Dandrifosse Dietary Fructans Modulate Polyamine Concentration in the Cecum of Rats J. Nutr., October 1, 2000; 130(10): 2456 - 2460. [Abstract] [Full Text]
|
|
|
|
|
|
H. N. Lærke, B. B. Jensen, and S. Højsgaard In Vitro Fermentation Pattern of D-Tagatose Is Affected by Adaptation of the Microbiota from the Gastrointestinal Tract of Pigs J. Nutr., July 1, 2000; 130(7): 1772 - 1779. [Abstract] [Full Text]
|
|
|
|
|
|
G. Le Blay, C. Michel, H. M Blottière, and C. Cherbut Prolonged Intake of Fructo-Oligosaccharides Induces a Short-Term Elevation of Lactic Acid-Producing Bacteria and a Persistent Increase in Cecal Butyrate in Rats J. Nutr., December 1, 1999; 129(12): 2231 - 2235. [Abstract] [Full Text]
|
|
|
|
|
|
B. S. Reddy Possible Mechanisms by Which Pro- and Prebiotics Influence Colon Carcinogenesis and Tumor Growth J. Nutr., July 1, 1999; 129(7): 1478 - 1478. [Abstract] [Full Text]
|
|
|
|
|
|
M. S Alles, R. Hartemink, S. Meyboom, J. L Harryvan, K. M. Van Laere, F. M Nagengast, and J. G. Hautvast Effect of transgalactooligosaccharides on the composition of the human intestinal microflora and on putative risk markers for colon cancer Am. J. Clinical Nutrition, May 1, 1999; 69(5): 980 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Trautwein, D. Rieckhoff, and H. F. Erbersdobler Dietary Inulin Lowers Plasma Cholesterol and Triacylglycerol and Alters Biliary Bile Acid Profile in Hamsters J. Nutr., November 1, 1998; 128(11): 1937 - 1943. [Abstract] [Full Text]
|
|
|
|
|
|
M. Kim and H. K. Shin The Water-Soluble Extract of Chicory Influences Serum and Liver Lipid Concentrations, Cecal Short-Chain Fatty Acid Concentrations and Fecal Lipid Excretion in Rats J. Nutr., October 1, 1998; 128(10): 1731 - 1736. [Abstract] [Full Text]
|
|
|
|
|
|
J. Noack, B. Kleessen, J. Proll, G. Dongowski, and M. Blaut Dietary Guar Gum and Pectin Stimulate Intestinal Microbial Polyamine Synthesis in Rats J. Nutr., August 1, 1998; 128(8): 1385 - 1391. [Abstract] [Full Text]
|
|
