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The Water-Soluble Extract of Chicory Reduces Glucose Uptake from the Perfused Jejunum in Rats^1,2,

Department of Food Science and Nutrition, Hallym University, Chunchon, 200-702, Korea

Among the components of dietary fiber, the soluble fibers have been found to impair glucose absorption. Little is known, however, about the mechanism of this effect. The direct action of soluble fibers (chicory water-soluble extract and inulin) on the intestinal absorption of glucose was investigated in gutperfused rats. After equilibrium, both jejunal and ileal segments were simultaneously perfused with an isotonic electrolyte solution (pH 7.4) containing glucose (10 mmol/L) and chicory water-soluble extract (chicory extract) or inulin (10 g/L). Each test or control solution was perfused in random sequence, with perfusion times of 30 min. Chicory extract or inulin in the perfusate (10 g/L) inhibited the absorption of glucose from jejunum (P < 0.05). The observed changes in glucose and water absorption caused by chicory extract or inulin were reversible after switching to a fiber-free perfusate. Additionally, net water absorption changed to secretion upon addition of chicory extract or inulin. These results suggest that the reduction in intestinal absorption of glucose observed after perfusion of chicory extract or inulin may be caused by viscosity-related increases in mucosal unstirred layer thickness.

KEY WORDS: • glucose uptake • dietary fibers • chicory • inulin • small intestine • rats

¹ The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

² Supported by the Highly Advanced National Project from the Ministry of Science and Technology, Korea.

³ To whom correspondence and reprint requests should be addressed.

Manuscript received 11 September 1995. Revision accepted 20 May 1996.