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Dietary Xylitol, Sorbitol and D-Mannitol but not Erythritol Retard Bone Resorption in Rats¹

Pauli T. Mattila^*,2, Martti J. Svanberg^*, Kauko K. Mäkinen and Matti L. E. Knuuttila^**

^* Institute of Dentistry, University of Oulu, 90220 Oulu, Finland School of Dentistry, University of Michigan, Ann Arbor, MI 48109 ^** Oral and Maxillofacial Department, Oulu University Hospital, 90220 Oulu, Finland

The aim of the present study was to compare the ability of four dietary polyols to reduce bone resorption. Urinary excretion of ³H radioactivity from [³H]tetracycline-prelabeled rats was used as a marker of bone resorption. After prelabeling, the rats were divided randomly into five groups of 10, and fed for 1 mo a nonpurified diet that was supplemented in four groups with either xylitol, sorbitol, D-mannitol or erythritol, respectively, to give a polyol concentration of 1 mol/kg. Xylitol (42%), sorbitol (44%) and to a lesser degree D-mannitol (23%) decreased the excretion of ³H relative to the basal diet. The erythritol group, however, did not differ from the controls. Sorbitol caused continuous diarrhea, whereas in the other groups, intestinal adaptation took place during the 1st wk of polyol feeding. In conclusion, dietary xylitol, sorbitol and to a lesser degree D-mannitol supplementations in rats retard bone resorption, whereas dietary erythritol has no effect.

KEY WORDS: • rats • polyols • bone resorption

¹ The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

² To whom reprint requests should be addressed at Institute of Dentistry, University of Oulu, Aapistie 3, SF-90220 Oulu, Finland.

Manuscript received 26 October 1995. Revision accepted 4 April 1996.