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Recombinant Bovine Somatotropin Decreases Hepatic Amino Acid Catabolism in Female Rats^1,2,

Departments of Meat and Animal Science ^* Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706

The effect of recombinant bovine somatotropin (rbST) on hepatic amino acid catabolism in female rats was investigated. Daily injections of rbST for 5 d decreased liver homogenate lysine -ketoglutarate reductase (EC 1.5.1.8) activity (P < 0.05) and liver homogenate lysine oxidation (P < 0.05) 35%. Liver homogenate methionine and valine oxidation were depressed 20 (P = 0.13) and 35% (P < 0.05), respectively. These data show a decrease in hepatic capacity to oxidize amino acids in rats administered rbST. Whether depressed liver amino acid degrading enzyme activity plays a role in amino acid oxidation in vivo remains to be evaluated.

KEY WORDS: • rats • somatotropin • lysine • methionine • valine

¹ Presented in part at the American Society of Animal Sciences Meeting, July 1994, Minneapolis MN [Gahl, M. J., Blemings, K. P., Benevenga, N. J. & Crenshaw, T. D. (1994) Protein synthesis, lysine oxidation and lysine -ketoglutarate reductase activity in female rats injected with bovine somatotropin. J. Anim. Sci. 72 (suppl. 1):221 (abs.)].

² The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

³ Current address: Farmland Industries, 3705 N. 137th St., Kansas City, KS 66109.

⁴ To whom correspondence should be addressed.

Manuscript received 26 May 1995. Revision accepted 22 February 1996.

This article has been cited by other articles:

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