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D-Tagatose Is a Bulk Sweetener with Zero Energy Determined in Rats^1,2,

Institute of Food Research, Norwich Laboratory, Colney, Norwich NR4 7UA, United Kingdom

The ketohexose D-tagatose is readily oxidized but contributes poorly to lipid deposition. We therefore examined whether this sugar contributes to energy requirements by determining its net metabolizable energy value in rats. All substrate-induced energy losses from D-tagatose, with sucrose as reference standard, were determined as a single value accounting for the sum of the energy losses to feces, urine, gaseous hydrogen and methane and substrate-induced thermogenesis. A randomized parallel design involving two treatment periods (adaptation to D-tagatose and subsequent energy balance) and two control groups (to control for treatment effects in each period) was used. Rats consumed 1.8 g test carbohydrate daily as a supplement to a basal diet for a 40- or 41-d balance period after prior adaptation for 21 d. Growth, protein and lipid deposition were unaffected by supplementary gross energy intake from D-tagatose compared with an unsupplemented control, but sucrose significantly (P < 0.05) increased all three. Based on the changes induced in protein and fat gain during the balance period it was calculated that D-tagatose contributed -3 ± 14% of its heat of combustion to net metabolizable energy, and therefore this ketohexose effectively has a zero energy value. D-Tagatose would potentially be helpful in body weight control, especially in diabetic subjects because of its antidiabetogenic effects.

KEY WORDS: • D-tagatose • net energy value • rats • body composition • supplement-induced energy loss

¹ Supported in part by Biospherics, Beltsville, MD.

² The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked as "advertisement" in accordance with 18USC section 1734 solely to indicate this fact.

³ To whom reprint requests should be addressed.

Manuscript received 2 November 1995. Revision accepted 1 February 1996.

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