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Oxidant-Antioxidant Status Alterations in Cancer Patients: Relationship to Tumor Progression^1,2,

Mariette Gerber^*,3, Cecile Astre, Claire Ségala^*, Monique Saintot^*, Jacqueline Scali^*, Joëlle Simony-Lafontaine, Jean Grenier and Henri Pujol

^* Groupe d'Epidémiologie Métabolique, INSERM-CRLC CRLC, 34298 Montpellier Cedex 5, France

A significant change of vitamin E and malondialdehyde plasma concentrations was reported in breast cancer patients. This change was unexpected because vitamin E was higher and malondialdehyde lower in cases than in controls, and the difference was more significant in young rather than older women. The first aim of this study was to determine whether these changes were associated only with breast cancer, or with hormone-related cancers, and/or cancers associated with nutritional risk factors or with all types of cancers. Measurements were performed before therapy on 269 hospital-based controls and on 146 patients with various carcinomas. Vitamin E:total cholesterol increased and malondialdehyde plasma concentration decreased with tumor size and progression, without relation to the site. The second aim was to understand the difference in the change observed between young and old breast cancer patients. These analytes were measured in 365 breast cancer patients according to three prognosis factors: pathology, tumor size and estrogen receptors. Vitamin E:total cholesterol significantly decreased with estrogen receptor amount. Malondialdehyde plasma concentration decreased with severity of pathology and tumor size. Together, these data support the association of an altered oxidant-antioxidant profile in cancer patients with tumor growth and progression.

KEY WORDS: • vitamin E • lipid peroxidation • tumor progression • case control study

¹ Presented as part of the Symposium: "Prooxidant Effects of Antioxidant Vitamins" given at the Experimental Biology '95 meeting, Atlanta, GA, on April 13, 1995. This symposium was sponsored by the American Institute of Nutrition. Guest editor for the symposium publication was Victor Herbert, the Mount Sinai School of Medicine, New York City, NY, and the Bronx Veterans Affairs Medical Center, Bronx, NY.

² Supported by contract INSERM 88-8012.

³ To whom correspondence should be addressed: Groupe d'Epidémiologie Métabolique, INSERM-CRLC, Epidaure 34298 Montpellier Cedex 5 France.