QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Thomas, M. J. Articles by Rudel, L. L. Search for Related Content PubMed PubMed Citation Articles by Thomas, M. J. Articles by Rudel, L. L.

Dietary Fatty Acids, Low Density Lipoprotein Composition and Oxidation and Primate Atherosclerosis^1,2,3,

Michael J. Thomas^*,4 and Lawrence L. Rudel^*,,

^* Departments of Biochemistry Comparative Medicine, Wake Forest University Medical Center, The Bowman Gray School of Medicine, Winston-Salem, NC 27157

Low density lipoproteins (LDL) were isolated from nonhuman primates fed isocaloric diets rich in different types of fatty acids. These diets contained 35% of calories as fat enriched in fatty acids from the following sources: lard that is rich in saturated fatty acids, safflower oil rich in oleic acid, safflower oil rich in linoleic acid and menhaden oil that is rich in n-3 fatty acids. LDL composition reflected the dietary fats. LDL were subjected to oxidation using copper ions and azobis(2-amidinopropane) · 2HCl. In general, the sensitivity of LDL to oxidation depended on both the polyunsaturated fatty acid and vitamin E content. However, the lag times calculated for the copper ion catalyzed oxidations did not show the linear dependence on vitamin E content that was found for azobis(2-amidinopropane) catalyzed oxidation.

KEY WORDS: • atherosclerosis • dietary fatty acids • LDL oxidation • nonhuman primates • vitamin E

¹ Presented as part of the symposium: "Formation, Metabolism and Physiologic Effects of Oxidatively Modified Low Density Lipoprotein" given at the Experimental Biology '95 meeting, Atlanta, GA, on April 12, 1995. This symposium was sponsored by the American Institute of Nutrition and was supported in part by Kraft General Foods, Inc. Guest editor for the symposium publication was Rachel Shireman, University of Florida, Gainesville, FL.

² Some of these results were presented at the 67th Meeting of the American Heart Association held November 14–17, 1994, in Dallas, TX.

³ Supported in part by a Forsyth County United Way Grant and NIH Grant HL-49373.

⁴ To whom correspondence should be addressed.

This article has been cited by other articles:

				W. B. Strawn, M. C. Chappell, R. H. Dean, S. Kivlighn, and C. M. Ferrario Inhibition of Early Atherogenesis by Losartan in Monkeys With Diet-Induced Hypercholesterolemia Circulation, April 4, 2000; 101(13): 1586 - 1593. [Abstract] [Full Text] [PDF]