QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Suárez, A. Articles by Gil, A. Search for Related Content PubMed PubMed Citation Articles by Suárez, A. Articles by Gil, A.

Dietary Long-Chain Polyunsaturated Fatty Acids Influence Tissue Fatty Acid Composition in Rats at Weaning^1,2,

Department of Biochemistry and Molecular Biology, Instituto de Nutrición y Tecnología de los Alimentos, University of Granada, Spain

We studied the fatty acid composition of plasma, plasma phospholipids, erythrocyte membrane lipids, liver microsomal phospholipids and brain lipids in rats fed three different diets varying in their (n-3) and (n-6) long-chain polyunsaturated fatty acid (LCP) concentrations for 0, 2 and 4 wk afte weaning. The three diets contained 10% fat; diet HO had a high-oleic acid proportion; diet FO was enriched in n-3 LCP provided by fish oil; and diet FO + BPL contained n-3 and n-6 LCP supplied by fish oil and a brain phospholipid concentrate. At 2 and 4 wk after weaning the proportions of oleic acid in all tissues, except in liver microsomes of the FO + BLP group, were significantly higher than in weanling rats. The absence of (n-3) LCP intake resulted in significantly lower levels of docosapentaenoic [20:5(n-3)] and 22:6(n-3) acids in plasma, plasma phosphoplipids, erythrocyte membrane lipids compared with rats at weaning. Dietary supplementation with (n-3) LCP (FO and FO + BPL groups) for 4 wk led to higher levels of 22:6(n-3) in all tissues compared with rats fed the HO fat. The proportions of 20:4(n-6) and total (n-6) LCP were significantly lower in all tissues from rats fed the FO diet than in rats at weaning and rats fed the HO diet. After 2 and 4 wk, rats fed the FO + BPL diet had significantly higher levels of 20:4(n-6) and total (n-6) LCP in plasma, plasma phospholipids, erythrocyte lipids and liver microsomal phospholipids; the brain also showed a higher content of those fatty acids after 4 wk. Our results suggest that dietary supplementation with 20:4(n-6) and 22:6(n-3) influences the concentration of 20:4-(n-6) and 22:6(n-3) in body tissues of rats after weaning.

KEY WORDS: • rats • arachidonic acid • docosahexaenoic acid • long-chain polyunsaturated fatty acids

¹ Supported by a grant from Puleva-Uniasa, Granada, Spain.

² The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

³ To whom correspondence should be addressed.

Manuscript received 31 December 1994. Revision accepted 21 December 1995.

This article has been cited by other articles:

				K. D. Stark, S.-Y. Lim, and N. Salem Jr. Artificial rearing with docosahexaenoic acid and n-6 docosapentaenoic acid alters rat tissue fatty acid composition J. Lipid Res., November 1, 2007; 48(11): 2471 - 2477. [Abstract] [Full Text] [PDF]

				E. J. Scholljegerdes, S. L. Lake, T. R. Weston, D. C. Rule, G. E. Moss, T. M. Nett, and B. W. Hess Fatty acid composition of plasma, medial basal hypothalamus, and uterine tissue in primiparous beef cows fed high-linoleate safflower seeds J Anim Sci, June 1, 2007; 85(6): 1555 - 1564. [Abstract] [Full Text] [PDF]