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Vitamin A Status of Indonesian Children Infected with Ascaris lumbricoides after Dosing with Vitamin A Supplements and Albendazole^1,2,3,

Sherry A. Tanumihardjo^*,4, Dewi Permaesih, Muherdiyantiningsih, Effendi Rustan, Kusnandi Rusmil, Alex C. Fatah, Steve Wilbur^**, Muhilal, Darwin Karyadi and James A. Olson^*

^* Department of Biochemistry and Biophysics, Iowa State University, Ames, IA the Nutrition Research and Development Center, Bogor, West Java, Indonesia ^** Helen Keller International, Jakarta, West Java, Indonesia

In developing countries, both marginal vitamin A status and intestinal helminths are common among children. Indonesian children (n = 309, 0.6–6.6 y), known to be infected with Ascaris lumbricoides, were randomized into six different treatment groups (A-F). The treatments included 210 µmol vitamin A supplement and a dose of 400 mg albendazole (5-propylthio-1H-benzimidazol-2-yl carbamic acid methyl ester) administered orally either at the same health visit (Groups B and F) or at different contact times during a 1-mo period (groups A, C, D and E). Vitamin A status was assessed both before and 3–4 wk after the treatments by the modified relative dose response (MRDR) test. Vitamin A supplementation was most important in improving the vitamin A status (P < 0.0001) of these children, whereas treatment for ascariasis alone (P = 0.370) and the statistical interaction between treatment for ascariasis and vitamin A (P = 0.752) were not. Serum retinol concentrations marginally improved (P = 0.051) in two of the groups that received vitamin A and albendazole but not in the third group that received vitamin A only. The MRDR test proved a better discriminator of the effects of these treatments on vitamin A status than changes in serum retinol concentrations.

KEY WORDS: • modified relative dose response • vitamin A assessment • Ascaris lumbricoides • albendazole • dehydroretinol • humans

¹ Supported by the Thrasher Research Fund-2808-2 and Smith-Kline Beecham Pharmaceuticals.

² The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

³ Journal paper J-15911 of the Iowa Agriculture and Home Economics Experiment Station, Ames, IA (Project 3035).

⁴ To whom correspondence and reprint requests should be addressed.

Manuscript received 25 May 1995. Revision accepted 23 October 1995.

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