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Soybean Protein Suppresses Hepatic Lipogenic Enzyme Gene Expression in Wistar Fatty Rats^1,2,

Tezukayama Gakuin College, Sakai, Osaka 590-01, Japan ^* Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., Yodogawa-ku, Osaka 532, Japan

The effects of dietary soybean protein on lipogenic enzyme gene expression in livers of genetically fatty rats (Wistar fatty) have been investigated. When Wistar fatty rats and their lean littermates (7–8-wk old) were fed a casein or soybean protein isolate diet containing hydrogenated fat (4% hydrogenated fat plus 1% corn oil) or corn oil (5%) for 3 wk, the hepatic messenger RNA concentrations and activities of lipogenic enzymes were significantly lower in rats fed soybean protein than in those fed casein, regardless of genotype or dietary fat. The conversion rates of thyroxine to triiodothyronine by liver microsomes and plasma triiodothyronine concentrations were lower in the fatty rats than in the lean rats and were significantly greater in rats fed soybean protein than in those fed casein. Conversely, plasma and liver triacylglycerol concentrations were lower in soybean protein-fed fatty and lean rats than in those fed casein. The body weight was less in the fatty rats fed soybean protein than in those fed casein after 3 wk of feeding. Moreover, dietary polyunsaturated fatty acids suppressed lipogenic enzyme gene expression in the lean rats but did not in the fatty rats. Dietary soybean protein appeared to be useful for the reduction of obesity.

KEY WORDS: • lipogenic enzyme gene expression • soybean protein • triiodothyronine • Wistar fatty rats

¹ Supported by a grant from Tezukayama Gakuin College and partially supported by Japan Private School Promotion funds.

² The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

³ To whom correspondence should be addressed.

Manuscript received 4 October 1994. Revision accepted 16 October 1995.

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