QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Choi, B.-R. Articles by Palmquist, D. L. Search for Related Content PubMed PubMed Citation Articles by Choi, B.-R. Articles by Palmquist, D. L.

High Fat Diets Increase Plasma Cholecystokinin and Pancreatic Polypeptide, and Decrease Plasma Insulin and Feed Intake in Lactating Cows^1,2,

Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691-4096

High fat diets often decrease feed intake in dairy cows; however, mechanisms underlying fat-induced depression of feed intake are yet to be established. The postulate that high fat diets decrease feed intake by increasing concentrations of lipid metabolites or satiety hormones in blood was tested by using eight multiparous Holstein cows in a simultaneously replicated 4 x 4 Latin-square design. Treatments were control diet with 1) no fat added, 2) 30 g/kg calcium salts of long-chain fatty acids, 3) 60 g/kg calcium salts of long-chain fatty acids, and 4) 90 g/kg calcium salts of long-chain fatty acids. Cows were fed once daily a diet of concentrate, corn silage, alfalfa haylage and alfalfa hay (50:25:14:11 on a dry matter basis). Dry matter and energy intakes were decreased by inclusion of calcium salts of long-chain fatty acids >30 g/kg of total diet dry matter (P = 0.0001). Plasma nonesterified fatty acids and triglyceride concentrations were increased linearly by feeding increasing amounts of fat (P < 0.003 and P = 0.0001, respectively), whereas plasma ß-hydroxybutyrate and glucose concentrations were not influenced by supplemental fat. Fat supplementation increased postfeeding plasma cholecystokinin concentrations and linearly increased plasma pancreatic polypeptide concentrations. Highest concentrations of plasma cholecystokinin (P < 0.001) and pancreatic polypeptide (P < 0.05) were observed in cows fed the 90 g/kg fat supplement. Plasma insulin was lowered linearly by feeding fat (P = 0.0001). Increased concentrations of cholecystokinin and pancreatic polypeptide were associated with decreased intakes of feed and energy, whereas insulin may not be involved in the control of feed intake in cows fed fat.

KEY WORDS: • dietary fat • feed intake • cholecystokinin • pancreatic polypeptide • dairy cows

¹ Salaries and research support provided by state and federal funds appropriated to the Ohio Agricultural Research and Development Center, The Ohio State University. Manuscript no. 8–96.

² The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

³ To whom correspondence should be addressed.

Manuscript received 7 March 1996. Revision accepted 16 July 1996.

This article has been cited by other articles:

				P. C. Garnsworthy, A. Lock, G. E. Mann, K. D. Sinclair, and R. Webb Nutrition, Metabolism, and Fertility in Dairy Cows: 1. Dietary Energy Source and Ovarian Function J Dairy Sci, October 1, 2008; 91(10): 3814 - 3823. [Abstract] [Full Text] [PDF]

				P. C. Garnsworthy, A. Lock, G. E. Mann, K. D. Sinclair, and R. Webb Nutrition, Metabolism, and Fertility in Dairy Cows: 2. Dietary Fatty Acids and Ovarian Function J Dairy Sci, October 1, 2008; 91(10): 3824 - 3833. [Abstract] [Full Text] [PDF]

				B. J. Bradford, K. J. Harvatine, and M. S. Allen Dietary Unsaturated Fatty Acids Increase Plasma Glucagon-Like Peptide-1 and Cholecystokinin and May Decrease Premeal Ghrelin in Lactating Dairy Cows J Dairy Sci, April 1, 2008; 91(4): 1443 - 1450. [Abstract] [Full Text] [PDF]

				U. Moallem, M. Katz, A. Arieli, and H. Lehrer Effects of Peripartum Propylene Glycol or Fats Differing in Fatty Acid Profiles on Feed Intake, Production, and Plasma Metabolites in Dairy Cows J Dairy Sci, August 1, 2007; 90(8): 3846 - 3856. [Abstract] [Full Text] [PDF]

				A. A. Fouladi-Nashta, C. G. Gutierrez, J. G. Gong, P. C. Garnsworthy, and R. Webb Impact of Dietary Fatty Acids on Oocyte Quality and Development in Lactating Dairy Cows Biol Reprod, July 1, 2007; 77(1): 9 - 17. [Abstract] [Full Text] [PDF]

				U. Moallem, M. Katz, H. Lehrer, L. Livshitz, and S. Yakoby Role of Peripartum Dietary Propylene Glycol or Protected Fats on Metabolism and Early Postpartum Ovarian Follicles J Dairy Sci, March 1, 2007; 90(3): 1243 - 1254. [Abstract] [Full Text] [PDF]

				A. E. Relling and C. K. Reynolds Feeding Rumen-Inert Fats Differing in Their Degree of Saturation Decreases Intake and Increases Plasma Concentrations of Gut Peptides in Lactating Dairy Cows J Dairy Sci, March 1, 2007; 90(3): 1506 - 1515. [Abstract] [Full Text] [PDF]

				T. R. Bilby, A. Sozzi, M. M. Lopez, F. T. Silvestre, A. D. Ealy, C. R. Staples, and W. W. Thatcher Pregnancy, Bovine Somatotropin, and Dietary n-3 Fatty Acids in Lactating Dairy Cows: I. Ovarian, Conceptus, and Growth Hormone-Insulin-Like Growth Factor System Responses. J Dairy Sci, September 1, 2006; 89(9): 3360 - 3374. [Abstract] [Full Text] [PDF]

				S. Hutchison, E. B. Kegley, J. K. Apple, T. J. Wistuba, M. E. Dikeman, and D. C. Rule Effects of adding poultry fat in the finishing diet of steers on performance, carcass characteristics, sensory traits, and fatty acid profiles J Anim Sci, September 1, 2006; 84(9): 2426 - 2435. [Abstract] [Full Text] [PDF]