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Selection for Growth Does Not Affect Apparent Energetic Efficiency of Jejunal Glucose Uptake in Mice^1,2,

Yang-Kwang Fan³, Warren J. Croom, Jr.^4,5,, Eugene J. Eisen, Linda R. Daniel, Betty L. Black^* and Brian W. McBride

Department of Animal Science ^* Department of Zoology, North Carolina State University, Raleigh, NC 27695 Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, N1G2W1, Canada

Five-wk-old male mice from high growth (M16) and randomly bred control (ICR) lines, plus their reciprocal crosses, ICR x M16 and M16 x ICR, were used to investigate whether whole-body O₂ consumption, jejunal respiration, jejunal glucose absorption and the apparent energetic efficiency of jejunal active glucose uptake in mice are altered by genetic selection for growth as well as by heterosis and maternal effects. Whole-body O₂ consumption was measured in 12 mice from each line or cross. The mice were later killed for measurement of jejunal O₂, using tissue respiration chambers and jejunal glucose transport determined by ³H-3-O-methylglucose accumulation. No heterosis or maternal effects were detected in jejunal glucose active transport and active glucose uptake. Selection for growth (M16 vs. ICR) increased daily gain (1.54 vs. 1.09 g, P < 0.001), small intestinal length and weight, but did not enhance jejunal glucose transport. The apparent energetic efficiency of jejunal active glucose uptake among lines was not different (54.0, 50.4, 51.6 and 47.1 nmol ATP expended/nmol glucose uptake for M16, ICR, M16 x ICR and ICR x M16, respectively, P > 0.63). Selection for growth in mice did not result in more energetically efficient jejunal glucose absorption.

KEY WORDS: • nutrient transport • glucose • oxygen consumption • intestine • mice

¹ The use of trade names in this publication does not imply endorsement by the North Carolina Agricultural Research Service of the products named or similar ones not mentioned.

² The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

³ Present address: Department of Animal Science, National Chung-Hsing University, Taichung, Taiwan.

⁴ Present address: Department of Poultry Science.

⁵ To whom correspondence and reprint requests should be addressed.

Manuscript received 14 November 1995. Revision accepted 7 July 1996.