QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wolever, T. M. S. Articles by Bolognesi, C. Search for Related Content PubMed PubMed Citation Articles by Wolever, T. M. S. Articles by Bolognesi, C.

Source and Amount of Carbohydrate Affect Postprandial Glucose and Insulin in Normal Subjects¹

Thomas M. S. Wolever^*,,**,2 and Claudia Bolognesi^*,3

^* Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2 Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada M5C 2T2 ^** Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada M5B 1W8

To determine if source and amount of carbohydrate affected postprandial glucose and insulin responses, seven nondiabetic subjects consumed 0, 25, 50, 75 or 100 g carbohydrate (total carbohydrate minus total dietary fiber) portions of barley, spaghetti, bread or potato. By ANOVA, both source and amount of carbohydrate had significant effects on incremental response areas for capillary glucose (P = 0.001), plasma glucose (P = 0.01) and plasma insulin (P = 0.03), but there was no source x amount interaction. By regression analysis, source of carbohydrate explained a similar amount of the variability of glucose and insulin responses, 46–64%, as the amount of carbohydrate, 47–57%. Together, carbohydrate source and amount accounted for 85–94% of the variability of mean glucose and insulin responses. We conclude that, for individual foods with different glycemic indices, both source and amount of carbohydrate influence the postprandial glucose and insulin responses of nondiabetic subjects.

KEY WORDS: • humans • glucose • insulin • glycemic index • carbohydrate

¹ The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

² To whom correspondence should be addressed.

³ CB was in receipt of a Rotary International Scholarship.

Manuscript received 25 March 1996. Revision accepted 11 July 1996.

This article has been cited by other articles:

				L. Jiao, A. Flood, A. F. Subar, A. R. Hollenbeck, A. Schatzkin, and R. Stolzenberg-Solomon Glycemic Index, Carbohydrates, Glycemic Load, and the Risk of Pancreatic Cancer in a Prospective Cohort Study Cancer Epidemiol. Biomarkers Prev., April 1, 2009; 18(4): 1144 - 1151. [Abstract] [Full Text] [PDF]

				K. Marsh and J. Brand-Miller State of the Art Reviews: Glycemic Index, Obesity, and Chronic Disease American Journal of Lifestyle Medicine, April 1, 2008; 2(2): 142 - 150. [Abstract] [PDF]

				J. A Monro and M. Shaw Glycemic impact, glycemic glucose equivalents, glycemic index, and glycemic load: definitions, distinctions, and implications Am. J. Clinical Nutrition, January 1, 2008; 87(1): 237S - 243S. [Abstract] [Full Text] [PDF]

				C. E. O'Neil and T. A. Nicklas State of the Art Reviews: Relationship Between Diet/ Physical Activity and Health American Journal of Lifestyle Medicine, December 1, 2007; 1(6): 457 - 481. [Abstract] [PDF]

				K. A Hatonen, M. E Simila, J. R Virtamo, J. G Eriksson, M.-L. Hannila, H. K Sinkko, J. E Sundvall, H. M Mykkanen, and L. M Valsta Methodologic considerations in the measurement of glycemic index: glycemic response to rye bread, oatmeal porridge, and mashed potato. Am. J. Clinical Nutrition, November 1, 2006; 84(5): 1055 - 1061. [Abstract] [Full Text] [PDF]

				M. C. Casiraghi, M. Garsetti, G. Testolin, and F. Brighenti Post-Prandial Responses to Cereal Products Enriched with Barley {beta}-Glucan. J. Am. Coll. Nutr., August 1, 2006; 25(4): 313 - 320. [Abstract] [Full Text] [PDF]

				A. E. Buyken, Y. Kellerhoff, S. Hahn, A. Kroke, and T. Remer Urinary C-Peptide Excretion in Free-Living Healthy Children Is Related to Dietary Carbohydrate Intake but Not to the Dietary Glycemic Index J. Nutr., July 1, 2006; 136(7): 1828 - 1833. [Abstract] [Full Text] [PDF]

				T. M. Wolever, M. Yang, X. Y. Zeng, F. Atkinson, and J. C Brand-Miller Food glycemic index, as given in Glycemic Index tables, is a significant determinant of glycemic responses elicited by composite breakfast meals Am. J. Clinical Nutrition, June 1, 2006; 83(6): 1306 - 1312. [Abstract] [Full Text] [PDF]

				M. L. Asp, S. R. Hertzler, J. Chow, and B. W. Wolf Gamma-Cyclodextrin Lowers Postprandial Glycemia and Insulinemia without Carbohydrate Malabsorption in Healthy Adults. J. Am. Coll. Nutr., February 1, 2006; 25(1): 49 - 55. [Abstract] [Full Text] [PDF]