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The Pathogenesis of HIV Disease¹

Molecular Histology, Inc., Gaithersburg, MD 20879

HIV disease is caused by human adapted Lentiviruses, a family of mammalian retroviruses that use the immune systems of their hosts to persist and, as their name implies (lenti = slow), to produce a disease state over long periods of time. The pathogenesis of HIV infections is now known in enough detail to make decisions about intervening in the course of the disease.

KEY WORDS: • HIV infection • pathogenesis • pediatric HIV infection

¹ Presented at the workshop entitled "Nutrition in Pediatric HIV Infection: Setting the Research Agenda" held in Bethesda, MD on September 28–29, 1995. The workshop was sponsored by the Office of AIDS Research of the National Institutes of Health, the National Institute of Child Health and Human Development, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Mental Health, Food and Drug Administration, Pediatric AIDS Foundation, National Dairy Council, Sandoz Nutrition Corporation, Bristol-Meyers Squibb Company, Clintec Nutrition Company, Ross Products Division-Abbott Laboratories, Serono Laboratories, Inc., and the American Institute of Nutrition. Workshop proceedings are published as a supplement to The Journal of Nutrition. Guest Editors for this supplement publication were Daniel J. Raiten and John M. Talbot, Life Sciences Research Office, Federation of American Societies for Experimental Biology, Bethesda, MD.