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Vitamin B-6 Status Indicators Decrease in Women Consuming a Diet High in Pyridoxine Glucoside^1,2,3,4,

Department of Nutrition and Food Management, Oregon State University, Corvallis, OR 97331

Previous research has shown that the pyridoxine glucoside (PNG) form of vitamin B-6 has a reduced bioavailability compared with pyridoxine, but its effect on vitamin B-6 status has not been assessed. Following an 8-d adjustment period, nine women consumed diets containing a high or low amount of PNG for 18 d each, in a crossover design. The high and low PNG diets provided 1.52 mg/d (8.98 µmol/d) and 1.44 mg/d (8.57 µmol/d) of vitamin B-6, of which 27% and 9% was PNG, respectively. The dietary vitamin B-6 to protein ratio of both diets was 0.017 mg/g. Urinary excretions of 4-pyridoxic acid and total vitamin B-6 were significantly lower (P < 0.05) during the high PNG diet period than when the low PNG diet was consumed. Urinary PNG excretion was equal to about 9% of the total PNG intake during both periods. Plasma total vitamin B-6 (P < 0.01) and red blood cell pyridoxal 5'-phosphate (PLP) (P < 0.05) were significantly lower when the high PNG diet was consumed than during the low PNG diet period. Fecal total vitamin B-6 excretion was significantly higher (P < 0.001) when the high PNG diet was consumed. Women consuming a diet containing a higher percentage of the total vitamin B-6 intake as PNG exhibited a decrease in vitamin B-6 status indicators, consistent with the reduced bioavailability of PNG demonstrated in other studies, equal to a loss of 15–18% of the total vitamin B-6 intake. During the determination of Recommended Dietary Allowances, the reduced bioavailability of PNG and its presence in higher amounts in some diets should be considered.

KEY WORDS: • pyridoxine glucoside • vitamin B-6 status • bioavailability • women

¹ Presented in part at the annual meeting of the Federation of American Societies for Experimental Biology, April 5–9, 1992, Anaheim, CA [Hansen, C., Leklem, J., Hardin, K., Miller, L. & Chen, W.-S. C. (1992) Effect of feeding diets of high and low pyridoxine content on vitamin B-6 status of women. FASEB J 6: A1374 (abs 2535)].

² Supported by USDA grant no. 88-37200-3520.

³ Paper no. 10,880 from Oregon Agricultural Experiment Station.

⁴ The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

⁵ To whom correspondence should be addressed.

Manuscript received 28 December 1995. Revision accepted 4 June 1996.

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