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Insulin Resistance, Obesity and Hypertension^1,2,

Division of Pediatric Cardiology, Department of Pediatrics University of Minnesota Hospitals and Clinics, Minneapolis, MN

Although controversy exists as to the role that insulin resistance and hyperinsulinemia play in the pathogenesis of hypertension, data are presented that strongly suggest that selective insulin resistance and hypertension are directly related. This paper summarizes how insulin resistance may be linked to obesity hypertension and describes some of the other cardiovascular implications that insulin resistance may have in the hypertensive obese individual.

KEY WORDS: • insulin resistence • obesity • high blood pressure

¹ Presented as part of the symposium "Insulin Resistance, Obesity and Hypertension" given at the Experimental Biology '94 meeting, Anaheim, CA, on April 27, 1994. This symposium was sponsored by the American Institute of Nutrition. Guest editor for this symposium was Michael B. Zemel, The University of Tennessee, Knoxville, TN.

² Supported in part by grants HL-18575, HL-35743, Hl 52205 and 2P60 AM 20572 from the National Institutes of Health.

³ To whom correspondence should be addressed: Division of Pediatric Cardiology, Variety Club Children's Hospital, University of Minnesota Medical School, Box 94, Minneapolis MN 55455.