QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nemere, I. Search for Related Content PubMed PubMed Citation Articles by Nemere, I.

Nongenomic Effects of 1,25-Dihydroxyvitamin D₃: Potential Relation of a Plasmalemmal Receptor to the Acute Enhancement of Intestinal Calcium Transport in Chick^1,2,3,

Department of Nutrition and Food Sciences, Utah State University, Logan, UT 84322-8700

A number of model systems now exist for studying the nonnuclear actions of the seco-steroid hormone 1,25(OH)₂D₃. The perfused duodenal loop of vitamin D-replete chicks has provided the best correlation between nonnuclear actions and a physiological end point, namely enhanced calcium transport. Recent progress has been made in identifying and purifying an integral protein of the basal lateral membrane that may be a receptor for 1,25(OH)₂D₃. Studies with analogues (particularly 1,25(OH)₂-7-dehydrocholesterol and 1,25(OH)₂-lumisterol₃) have provided definite correlations between binding to the solubilized membrane receptor and the ability to initiate transcaltachia (the rapid hormonal stimulation of calcium transport).

KEY WORDS: • 1,25-dihydroxyvitamin D₃ • membrane receptor • calcium transport • chick intestine

¹ Presented as part of the symposium "Pleiotropic Actions of Vitamin D" given at the Experimental Biology '94 meeting, Anaheim, CA, on April 26, 1994. This symposium was sponsored by the American Institute of Nutrition. Guest editor for this symposium was Anthony W. Norman, University of California, Riverside, CA.

² Supported by USPHS grants DK-09012 (A. W. Norman) and DK 16-595 (W. H. Okamura).

³ A portion of these data were published in abstract form [Nemere, I. & Norman, A. W. (1992) Mol. Biol. Cell 3 (suppl): 297a].

⁴ To whom correspondence should be addressed: Department of Nutrition and Food Sciences, Utah State University, Logan, UT 84322-8700.

This article has been cited by other articles:

				A. Moeenrezakhanlou, L. Shephard, L. Lam, and N. E. Reiner Myeloid cell differentiation in response to calcitriol for expression CD11b and CD14 is regulated by myeloid zinc finger-1 protein downstream of phosphatidylinositol 3-kinase J. Leukoc. Biol., August 1, 2008; 84(2): 519 - 528. [Abstract] [Full Text] [PDF]

				A. Moeenrezakhanlou, D. Nandan, L. Shephard, and N. E. Reiner 1{alpha},25-Dihydroxycholecalciferol activates binding of CREB to a CRE site in the CD14 promoter and drives promoter activity in a phosphatidylinositol-3 kinase-dependent manner J. Leukoc. Biol., May 1, 2007; 81(5): 1311 - 1321. [Abstract] [Full Text] [PDF]

				R. M. LOSEL, E. FALKENSTEIN, M. FEURING, A. SCHULTZ, H.-C. TILLMANN, K. ROSSOL-HASEROTH, and M. WEHLING Nongenomic Steroid Action: Controversies, Questions, and Answers Physiol Rev, July 1, 2003; 83(3): 965 - 1016. [Abstract] [Full Text] [PDF]