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Do Polyunsaturated Fatty Acids Protect Against Oxidant-Induced Lung Damage?¹

Department of Pediatrics, (R-131), University of Miami School of Medicine, Miami, FL 33101

Little disagreement exists concerning the importance of early provision of lipid nutrition to very low birth weight (VLBW) infants in terms of growth and development. However, considerable controversy surrounds the relationship of lipid and protection against oxidant-induced lung damage in experimental situations and in the vulnerable premature infant. This article reviews the results of experimental and clinical studies on the protective effects of lipids against oxidant injury and chronic lung disease.

KEY WORDS: • polyunsaturated fatty acid • oxygen toxicity • chronic lung disease • oxidant lung injury • intralipid

¹ Presented as part of the symposium "Role of Nutrition in Lung Development and Function" given at the Experimental Biology '94 meeting, Anaheim, CA, on April 25, 1994. This symposium was sponsored by the American Institute of Nutrition. Guest editor for this symposium was John S. Torday, University of Maryland, Baltimore, MD.

² To whom correspondence should be addressed: Department of Pediatrics, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101.