QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Zhao, X. Articles by Donovan, S. M. Search for Related Content PubMed PubMed Citation Articles by Zhao, X. Articles by Donovan, S. M.

Human Growth Hormone but Not Human Insulin-Like Growth Factor-I Enhances Recovery from Neonatal Malnutrition in Rats^1,2,3,

Division of Foods and Nutrition, University of Illinois, Urbana, IL 61801 ^* Department of Medicine, University of Illinois and VA West Side Medical Center, Chicago, IL 60612

The ability of hormonal therapy to enhance recovery from neonatal mainutrition was assessed in rats. Pups were mainourished via maternal food restriction (60% control intake). On d 16, restricted pups (n = 50) (62% control body wt) were refed until d 20 and were given growth hormone, insulin-like growth factor-I, destripeptide [1,3] insulin-like growth factor-I, or saline (placebo). Refed-placebo pups attained 80% of control body weight by d 20. Growth hormone treatment caused a greater weight gain than refeeding alone (P 0.05). Treatment with insulin-like growth factor-I and destripeptide [1,3] insulin-like growth factor-I did not affact body weight. All three hormones increased spleen and kidney weights (P 0.05) compared with the refedplacebo group, whereas only growth hormone increased muscle weight (P 0.05). Mainourished pups had lower serum insulin-like growth factor-I (P 0.05) and insulin-like growth factor binding protein-3 (P 0.05), and higher serum insulin-like growth factor binding protein-2 (P 0.05) and hepatic insulin-like growth factor binding protein-2 mRNA (P 0.05) than controls. Refeeding increased serum insulin-like growth factor-I compared with restricted pups (P 0.05), and insulin-like growth factor-I treatment caused a further increased in serum insulin-like growth factor-I compared with the refedplacebo group (P 0.05). These results show that growth hormone was moderately effective at increasing body weight gain and muscle growth during recovery from mainutrition.

KEY WORDS: • insulin-like growth factor • growth hormone • rats • protein-energy mainutrition

¹ Supported by funding from the University of Illinois Agricultural Experiment Station (SMD), a Future Leader Award from the International Life Sciences Institute-Nutrition Foundation (SMD), NIH grant R-29 DK 41430 (TGU) and the Department of Veterans Affairs Merit Review Program (TGU).

² The data has been presented in part in the following two abstracts: Donovan, S. M., Monaco, M. & Zhao, X. (1992) Hormonal treatment during recovery from malnutrition: effects on body weight, organ growth, and IGF binding proteins. Proceedings of the 74th Annual Meeting of The Endocrine Society, p. 340 (abs.) and Zhao, X. & Donovan, S. M. (1993) GH and IGF-I treatment during recovery from malnutrition. FASEB J. 7: A361 (abs.).

³ The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

⁴ To whom correspondence should be addressed.

Manuscript received 15 August 1994. Revision accepted 12 December 1994.