QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fushiki, T. Articles by Sugimoto, E. Search for Related Content PubMed PubMed Citation Articles by Fushiki, T. Articles by Sugimoto, E.

Swimming Endurance Capacity of Mice is Increased by Chronic Consumption of Medium-Chain Triglycerides¹

Laboratory of Nutritional Chemistry, Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606, Japan

The effect of chronic administration of medium-chain triglycerides (MCT) on swimming endurance (swim capacity) was investigated in male Std ddY mice. The mice were fed a diet containing 80 g MCT + 20 g long-chain triglycerides (LCT)/kg diet for 6 wk; mice fed diet containing 100 g LCT/kg diet were used as controls. After being accustomed to swimming, the mice were subjected to forced swimming every 2 d in the current water pool that we had developed, and the total swimming period until exhaustion was measured. The total swimming period was used as the index of swim capacity. The group fed MCT showed significantly greater swim capacity than the control group (89.5 ± 2.5 vs. 80.2 ± 2.0 min). In another experiment, after 4 wk of MCT diet consumption, significantly greater swim capacity was found in untrained mice. The major metabolic consequences of the adaptations of muscle to prolonged MCT administration during endurance training were higher activities of 3-oxo acid CoA-transferase (P < 0.01), citrate synthase (P < 0.1) and malate dehydrogenase (P < 0.1). These findings suggest that increases in the enzyme activities of the tricarboxylic acid cycle and ketone body utilization associated with the chronic administration of an MCT-containing diet enhance swim capacity in mice.

KEY WORDS: • medium-chain triglycerides • mice • swimming capacity • ketone body utilization

¹ The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

² To whom correspondence and reprint requests should be addressed.

Manuscript received 7 February 1994. Revision accepted 1 September 1994.

This article has been cited by other articles:

				M. Newell-McGloughlin Nutritionally Improved Agricultural Crops Plant Physiology, July 1, 2008; 147(3): 939 - 953. [Full Text] [PDF]

				D. Bernstein Exercise assessment of transgenic models of human cardiovascular disease Physiol Genomics, May 13, 2003; 13(3): 217 - 226. [Abstract] [Full Text] [PDF]