![]() |
|
|
,4
,4
Department of Medicine, University of Berne, Inselspital, CH-3010 Berne, Switzerland
* Department of Anesthesiology and Intensive Care, Huddinge University Hospital, Karolinska Institute, S-141 86 Huddinge, Sweden
Rowett Research Institute, Aberdeen AB2 9SB, Scotland
The response of albumin synthesis rates to infusion of either an intravenous nutrient mixture containing adequate nitrogen and energy or an isotonic saline infusion was compared in adult men. In a crossover study, nine healthy male subjects received a short-term (13.5-h) infusion of either the nutrient mixture or the saline solution, and albumin synthesis rates were measured by a stable isotope technique employing [2H5ring]phenylalanine. Fractional rates of albumin synthesis did not differ significantly between treatments (saline, 7.3 ± 1.0%/d; intravenous nutrients, 7.8 ± 1.0%/d). The secretion time of albumin was significantly lower with intravenous nutrients infusion than with saline infusion. Plasma albumin concentration as well as prealbumin and transferrin concentrations decreased over time when subjects were infused with either saline or the nutrient solution as a result of dilution rather than a change in synthesis. These results suggest that albumin synthesis rate does not respond to short-term intravenous nutrients.
KEY WORDS: protein synthesis stable isotope albumin phenylalanine humans
1 Supported by the Swiss National Foundation, grant no. 32-31290.91 (P.E.B.), Nestec Ltd., Switzerland (M.A.M.), the Swedish Research Council, project no. 04210 (P.E.), and Grampian Research into Intestinal Disorders. The Rowett Research Institute is supported by the Scottish Office Agriculture and Fisheries Department.
2 The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.
3 To whom correspondence should be addessed.
4 Current address: Department of Surgery, State University of New York at Stony Brook, Stony Brook, NY 11794.
Manuscript received 18 April 1994. Revision accepted 18 August 1994.
This article has been cited by other articles:
![]() |
D. Dardevet, S. R Kimball, L. S Jefferson, A. D Cherrington, D. Remond, C. A DiCostanzo, and M. C. Moore Portal infusion of amino acids is more efficient than peripheral infusion in stimulating liver protein synthesis at the same hepatic amino acid load in dogs Am. J. Clinical Nutrition, October 1, 2008; 88(4): 986 - 996. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. H. van den Akker, F. W. te Braake, H. Schierbeek, T. Rietveld, D. J. Wattimena, J. E. H Bunt, and J. B van Goudoever Albumin synthesis in premature neonates is stimulated by parenterally administered amino acids during the first days of life Am. J. Clinical Nutrition, October 1, 2007; 86(4): 1003 - 1008. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. E. H. Bunt, T. Rietveld, H. Schierbeek, J. L. D. Wattimena, L. J. I. Zimmermann, and J. B. van Goudoever Albumin synthesis in preterm infants on the first day of life studied with [1-13C]leucine Am J Physiol Gastrointest Liver Physiol, April 1, 2007; 292(4): G1157 - G1161. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Bos, B. Stoll, H. Fouillet, C. Gaudichon, X. Guan, M. A. Grusak, P. J. Reeds, D. G. Burrin, and D. Tome Postprandial intestinal and whole body nitrogen kinetics and distribution in piglets fed a single meal Am J Physiol Endocrinol Metab, February 1, 2005; 288(2): E436 - E446. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Shen, P. Wisniowski, L. Ahmed, D. W. Boyle, S. C. Denne, and E. A. Liechty Protein anabolic effects of insulin and IGF-I in the ovine fetus Am J Physiol Endocrinol Metab, April 1, 2003; 284(4): E748 - E756. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Barle, B. Nyberg, K. Andersson, P. Essen, M.A. McNurlan, J. Wernerman, and P. J. Garlick The Effects of Short-Term Parenteral Nutrition on Human Liver Protein and Amino Acid Metabolism During Laparoscopic Surgery JPEN J Parenter Enteral Nutr, November 1, 1997; 21(6): 330 - 335. [Abstract] [PDF] |
||||