QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schwab, U. S. Articles by Uusitupa, M. I. J. Search for Related Content PubMed PubMed Citation Articles by Schwab, U. S. Articles by Uusitupa, M. I. J.

Lauric and Palmitic Acid-Enriched Diets have Minimal Impact on Serum Lipid and Lipoprotein Concentrations and Glucose Metabolism in Healthy Young Women^1,2,

Department of Clinical Nutrition and A. I. Virtanen Institute, University of Kuopio, 70211 Kuopio ^* Department of Internal Medicine and Biocenter Oulu, University of Oulu, 90220 Oulu, Finland

Fifteen healthy young women were fed diets enriched to 4% of energy with either palmitic acid (as palm oil) or lauric acid (as coconut oil). A randomized crossover study design was used so that subjects followed the two experimental diets for 4 wk, both preceded by consumption of a baseline diet for 2 wk. The experimental diets differed only with respect to the fatty acid composition: there was a substitution of 4% of energy intake with palmitic acid or lauric acid in the experimental diets for 4% of energy as monoenes in the baseline diet. There were no differences in the concentration of serum total or lipoprotein lipids, apolipoproteins A-I and B, and lipoprotein (a) or plasma cholesteryl ester transfer protein activity between the experimental diet periods. The VLDL cholesterol concentration (0.38 ± 0.05 vs. 0.51 ± 0.05 mmol/L, means ± SEM, P = 0.01] and plasma cholesteryl ester transfer protein activity [78 ± 5 vs. 88 ± 6 µmol/(h·L), P = 0.007) were greater at the end of the lauric acid diet period than at the end of the preceding baseline diet period. No differences were found in glucose effectiveness, insulin sensitivity index or insulin secretion measured by the intravenous glucose tolerance test (Minimal Model method). In conclusion, in terms of serum lipids, lipoproteins, and glucose metabolism, palmitic acid was equal to lauric acid at 4% of total energy intake exchange, and both of these saturated fatty acids were comparable to a 4% of total energy intake exchange with monoenes in healthy young women.

KEY WORDS: • lauric acid • glucose • humans • lipoproteins • palmitic acid

¹ Supported by the Foundation for Nutrition Research; the Finnish Cultural Foundation; the Finnish Heart Research Foundation and the Medical Council of the Academy of Finland.

² The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

³ To whom correspondence should be addressed at Lipid Metabolism Laboratory, USDA HNRCA/Tufts University, 711 Washington Street, Boston, MA 02111.

⁴ To whom requests for reprints should be addressed.

Manuscript received 12 April 1994. Revision accepted 23 August 1994.

This article has been cited by other articles:

				M. P Corcoran, S. Lamon-Fava, and R. A Fielding Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise Am. J. Clinical Nutrition, March 1, 2007; 85(3): 662 - 677. [Abstract] [Full Text] [PDF]

				K. McAuley and J. Mann Thematic review series: Patient-Oriented Research. Nutritional determinants of insulin resistance J. Lipid Res., August 1, 2006; 47(8): 1668 - 1676. [Abstract] [Full Text] [PDF]

				R Buettner, K G Parhofer, M Woenckhaus, C E Wrede, L A Kunz-Schughart, J Scholmerich, and L C Bollheimer Defining high-fat-diet rat models: metabolic and molecular effects of different fat types. J. Mol. Endocrinol., June 1, 2006; 36(3): 485 - 501. [Abstract] [Full Text] [PDF]

				R. Jiang, J. E. Manson, M. J. Stampfer, S. Liu, W. C. Willett, and F. B. Hu Nut and Peanut Butter Consumption and Risk of Type 2 Diabetes in Women JAMA, November 27, 2002; 288(20): 2554 - 2560. [Abstract] [Full Text] [PDF]