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Activities of Antioxidant Enzymes in Various Tissues of Male Fischer 344 Rats Are Altered by Food Restriction^1,2,

Geriatric Research, Education and Clinical Center, Audie L. Murphy Memorial Veterans Hospital, and Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78284

The objective of this study was to determine how food restriction (40% restriction of food intake) altered the age-related changes in the activities of Cu,Zn superoxide dismutase, catalase and glutathione peroxidase in liver, brain cortex, heart, kidney and intestinal mucosa obtained from 6-, 16- and 26-mo-old male Fischer 344 rats. Food restriction increased the activity of one or more of the antioxidant enzymes in the liver, brain cortex, heart and kidney of the rats. However, the magnitude of the effect and the antioxidant enzyme(s) affected by food restriction varied from tissue to tissue, and food restriction had no significant effect on the activities of these enzymes in intestinal mucosa. Interestingly, the four tissues in which food restriction increased the activity of one or more of the antioxidant enzymes showed reduced lipid peroxidation as measured by thiobarbituric acid-reactive material. These data suggest that food restriction might enhance the survival of rodents by altering the levels of the antioxidant enzymes and hence reducing free radical damage.

KEY WORDS: • glutathione peroxidase • food restriction • superoxide dismutase • catalase • rats

¹ Supported in part by grant AG01548 from the National Institute on Aging and by the Office of Research and Development, Department of Veterans Affairs.

² The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

³ To whom correspondence should be addressed.

Manuscript received 18 April 1994. Revision accepted 5 August 1994.

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