QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kim, K.-H. Articles by Tae, H.-J. Search for Related Content PubMed PubMed Citation Articles by Kim, K.-H. Articles by Tae, H.-J.

Pattern and Regulation of Acetyl-CoA Carboxylase Gene Expression^1,2,3,

Department of Biochemistry, Purdue University, West Lafayette, IN 47907

Acetyl-CoA carboxylase is the rate-limiting enzyme in the biogenesis of long chain fatty acids. There is a single copy of the gene for acetyl-CoA carboxylase per haploid chromosome set. The gene contains two promoters whose primary transcripts are differentially spliced resulting in multiple forms of acetyl-CoA carboxylase mRNA. These mRNA species are different in the 5'-untranslated region, but contain the same coding region. Generation of different forms of the mRNA is tissue specific and controlled by physiological conditions. Two promoters contain an extensive array of cis-elements that perceive changes in the cellular environment signalling repression and induction of long chain fatty acid synthesis. The ability of the gene to respond to various lipogenic signals and the presence of the same coding sequence in all acetyl-CoA carboxylase mRNA species suggest that the biosynthesis of fatty acids required for multiple functions in the cells is primarily regulated at the gene level.

KEY WORDS: • fatty acids • gene expressions • acetyl-coenzyme A carboxylase gene • regulation of the gene expression

¹ This research is supported in part by NIH grant CA 46882.

² This is journal paper number 13916 from the Agricultural Experiment Station, Purdue University.

³ Presented as part of the symposium "Dietary Fat and Gene Expression." given at the Experimental Biology '93 meeting, New Orleans, LA, March 28 – April 1, 1993. The symposium was sponsored by the American Institute of Nutrition and the American Society for Clinical Nutrition. The guest editor for this symposium was Willard J. Visek, Department of Internal Medicine, University of Illinois College of Medicine, Urbana, IL.

This article has been cited by other articles:

				A. Canovas, J. Estany, M. Tor, R. N. Pena, and O. Doran Acetyl-CoA carboxylase and stearoyl-CoA desaturase protein expression in subcutaneous adipose tissue is reduced in pigs selected for decreased backfat thickness at constant intramuscular fat content J Anim Sci, December 1, 2009; 87(12): 3905 - 3914. [Abstract] [Full Text] [PDF]