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Viscous Indigestible Polysaccharides Reduce Accumulation of Pentachlorobenzene in Rats^1,2,

Division of Food Science ^* Division of Applied Food Research, The National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162, Japan

To investigate an effect of indigestible polysaccharides (cellulose as control, sodium alginate, guar gum or -carrageenan) on the accumulation of pentachlorobenzene, male Sprague Dawley rats were fed experimental diets containing 5 g/100 g of these polysaccharides for 2 wk. They were then given orally 80 µmol (20 mg) of pentachlorobenzene along with their respective diets and the residual pentachlorobenzene was determined after 7 d. The ingestion of the viscous indigestible polysaccharides resulted in significantly lower accumulation of pentachlorobenzene in adipose tissue, liver and kidney than that found in rats fed a cellulose diet. Soon (5 h) after pentachlorobenzene administration, its concentration in the blood of rats fed sodium alginate and guar gum was higher than that of rats fed cellulose, but lower in the groups fed all three viscous polysaccharides after d 3. These results indicate that pentachlorobenzene excretion was increased by the ingestion of viscous indigestible polysaccharides. Lower relative weight of adipose tissue, a storage tissue for pentachlorobenzene, was found in the rats fed sodium alginate and guar gum. The lower adipose tissue mass was likely the main contributor to the enhancement of pentachlorobenzene excretion.

KEY WORDS: • guar gum • cellulose • rats • pentachlorobenzene • sodium alginate

¹ Supported by the Environmental Agency, Japan.

² The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

³ To whom correspondence and reprint requests should be addressed.

⁴ Current address: Division of Home Economy, Mukogawa Women's College, Nishinomia, Hyogo 664, Japan.

Manuscript received 27 July 1993. Revision accepted 4 January 1994.