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Conjugated Linoleic Acid Is a Growth Factor for Rats as Shown by Enhanced Weight Gain and Improved Feed Efficiency^1,2,

Food Research Institute, Department of Food Microbiology and Toxicology ^* Department of Poultry Science, University of Wisconsin-Madison, Madison, WI 53706

We studied the effect of conjugated linoleic acid (CLA) on rat development and growth. Primigravid female Fischer rats were fed control or CLA-supplemented (0.25% or 0.5% CLA) diets during gestation and/or lactation. Conjugated linoleic acid was incorporated into milk fat and tissue lipids proportional to the level of CLA fed and the duration of CLA feeding. Conjugated linoleic acid was incorporated into fetal and neonatal tissues; it did not affect litter size nor induce apparent abnormalities. To the contrary, feeding CLA to the dams during gestation and lactation improved the postnatal body weight gain of pups (P < 0.05), measured on d 10 of lactation. Pups that continued to receive the CLA-supplemented diet after weaning had significantly greater body weight gain and improved feed efficiency relative to control animals (P < 0.05).

KEY WORDS: • conjugated linoleic acid • rats • feed efficiency • growth enhancement

¹ Supported in part by the College of Agricultural and Life Sciences, University of Wisconsin-Madison, and gift funds administered through the Food Research Institute, University of Wisconsin-Madison.

² The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

³ To whom correspondence should be addressed.

Manuscript received 18 January 1994. Revision accepted 3 June 1994.

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