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Enteral Formula Composition Does Not Affect Response to Lethal Infectious Challenge in Mice¹

Abbott Laboratories, Anti-infective Research Division, Abbott Park, IL 60064-3500 ^* Ross Products Division, Columbus, OH 43215

The effects of enteral formulations on the response of mice to infectious challenge with Listeria monocytogenes, influenza A or Candida albicans were studied to test the efficacy of specialized ingredients. CF-1 outbred female mice (12–15 g) were fed nonpurified diet (Purina No. 5002) or commercially available liquid formulas: Osmolite HN®, Perative® or Impact®. There were no differences between the groups fed the liquid formulas with regards to mean survival time or percentage of survivors in any of these models of infection. Examination of spleens from the groups challenged with L. monocytogenes, lungs from mice infected with Influenza A and kidneys from the groups challenged with C. albicans revealed no differences in cure rate of survivors. Pre-feeding periods of up to 8 d before infection produced similar results for mice fed enteral formulations compared to nonpurified diet. Contrary to previous reports, the use of Impact® did not improve resistance to disease in mice challenged with lethal doses of L. monocytogenes, as compared with mice fed Osmolite HN. Additionally, mice fed Impact®, Perative®, or nonpurifled diet responded similarly to challenge with L. monocytogenes, C. albiçans or influenza A. The results indicate that these acute lethal animal models of infectious challenge may be of limited use to distinguish effects of modified nutrient composition of enteral formulas.

KEY WORDS: • animal models • mice • enteral formula • infection

¹ The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

² To whom correspondence should be addressed.

Manuscript received 7 January 1994. Revision accepted 22 April 1994.

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