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Nutritional Status and Immune Responses in Mice with Murine AIDS Are Normalized by Vitamin E Supplementation^1,2,3,

Yuejian Wang^*,,, Dennis S. Huang^*,,, Bailin Liang^*,, and Ronald R. Watson^*,4

^* Department of Family and Community Medicine Nutritional Sciences Program Department of Microbiology and Immunology Department of Nutritional Sciences, University of Arizona, Tucson, AZ 85724

Female C57BL/6 mice were infected with LP-BM5 retrovirus, causing murine AIDS, which is functionally similar to human AIDS. Vitamin E effects on immune functions, cytokine production and nutritional concentrations in retrovirus-infected mice were determined. Retrovirus infection inhibited release of interleukin-2 (IL) and interferon- (IFN) and some immune functions, whereas it stimulated secretion of IL-4, IL-5, IL-6 and tumor necrosis factor- (TNF) and immunoglobulin (Ig) production. Furthermore, retrovirus infection induced some nutritional deficiencies in the tissues. A 15-fold increase in dietary vitamin E largely restored concentrations of some micronutrients (vitamins A and E, zinc and copper) in the liver, intestine, serum and thymus. It also partially restored production of IL-2 and IFN- by splenocytes. Retrovirus-induced elevated production of IL-4, IL-5 and IL-6 by splenocytes in vitro was normalized by vitamin E. Elevated release of IL-6, TNF-, IgA and IgG produced by splenocytes in vitro during murine AIDS were also completely or partially normalized by vitamin E. Vitamin E also prevented retrovirus-induced suppression of splenocyte proliferation and natural killer cell activity. These data indicate that vitamin E supplementation during murine AIDS can help to ameliorate the disorders during murine AIDS, suggesting vitamin E usefulness in treatment of AIDS in humans.

KEY WORDS: • vitamin E • cytokine • mice • murine AIDS • immune response

¹ Part of this work was presented as a poster at Experimental Biology 93, March 28–April 1, 1993, New Orleans, LA, and published in abstract form [Wang, Y., Huang, D. S., Wood, S., Lopez, M. C., Giger, P. T., Murphy, L. & Watson, R. R. (1993) Vitamin E supplementation assists in the restoration of imbalanced cytokine production induced by murine LP-BM5 retrovirus causing murine AIDS. FASEB J. 7: A285 (abs.)].

² Supported by NIH AA 08037.

³ The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

⁴ To whom correspondence should be addressed.

Manuscript received 24 September 1993. Revision accepted 18 April 1994.

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