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Departments of Medicine and Biochemistry and the Clinical Research Center, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee, WI 53226
The administration of 60 mmol/d of KHCO3 to healthy adults reduced urinary calcium excretion by 0.9 mmol/d and caused calcium balance to become equivalently more positive. Other studies showed that 90 mmol/d of KHCO3 reduced both daily and fasting urinary calcium excretion rates, whereas deprivation of either KCl or KHCO3, using synthetic diets, was accompanied by increased daily and fasting urinary calcium excretion rates. A significant inverse relationship between the changes in urinary calcium and the changes in urinary potassium was observed: 
urinary Ca (mmol/d) = 0.29 - 0.015 urinary K (mmol/d); r = -0.65. Correlative evaluation of additional data suggested that the fall in urinary calcium during potassium administration may be related to the natriuretic effects of potassium, resulting in ECF-volume contraction or to potassium-induced phosphate retention and suppression of calcitriol synthesis, or to both mechanisms.
KEY WORDS: • humans • calcium • potassium
1 Presented as part of the third Annual Workshop of Nutrition and Bone Health Group given at the Annual Meeting of the American Society for Bone and Mineral Research, October 3, 1992, Minneapolis, MN. Financial support for the workshop was provided by a grant from the National Dairy Council, Rosemont, IL. Guest editor for this supplement was L. K. Massey, Department of Food Science and Human Nutrition, Washington State University, Spokane, WA.
2 Supported in part by USPHS RR-00058 and DK-15089.
3 The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.
4 To whom correspondence should be addressed: 9200 West Wisconsin Avenue, Milwaukee, WI 53226.
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