QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Atkinson, S. A. Articles by Gibson, R. S. Search for Related Content PubMed PubMed Citation Articles by Atkinson, S. A. Articles by Gibson, R. S.

A Multi-Element Isotopic Tracer Assessment of True Fractional Absorption of Minerals from Formula with Additives of Calcium, Phosphorus, Zinc, Copper and Iron in Young Piglets^1,2,

Stephanie A. Atkinson³, Jay K. Shah, Colin E. Webber^*, Ian L. Gibson and Rosalind S. Gibson^**

Departments of Pediatrics ^* Nuclear Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada ^** Applied Human Nutrition, Department of Family Studies, University of Guelph, Guelph, ON, Canada Department of Earth Sciences, University of Waterloo, Waterloo, ON, Canada

True fractional absorption of minerals was measured to determine the bioavailability of Zn, Fe, Mn and Se from liquid formulas fortified with stepwise additions of Ca and P (as Ca glycerophosphate and carbonate, Ca*P), and Zn, Cu and Fe (as sulfate salts). Growth, deposition of tracers in organs and bone mineral content of femurs as assessed by single photon absorptiometry were measured. Four-day-old piglets (n = 36) were randomly assigned to groups fed a basal diet or additions of Ca*P (Ca = 25, P = 18 g/kg dry diet), Ca*P+Zn (Zn = 0.04 g/kg), Ca*P+Zn+Cu (Cu = 0.007 g/kg) or Ca*P+Zn+Cu+Fe (Fe = 0.008 g/kg). Oral and intravenous administration of extrinsic isotopes of ⁵⁹Fe, ⁵⁴Mn, ⁶⁵Zn, ⁷⁵Se and ⁴⁷Ca was followed by fecal monitoring for 15 d and true absorption calculated after accounting for endogenous excretion. Addition of Ca*P+Zn reduced Zn absorption (P < 0.05) and Ca*P+Zn+Cu reduced Fe absorption (P < 0.01), but Mn and Se absorptions were not altered. Uptake of only Zn tracer into heart was significantly different (P < 0.05) among diet groups. Weight gain and linear growth were similar in all groups. Addition of Ca*P produced higher bone mineral density, but its effect on Zn absorption warrants further investigation.

KEY WORDS: • trace minerals • bone density • piglets • calcium • bioavailability

¹ Supported by a grant from the Medical Research Council of Canada. S. A. Atkinson holds a Career Scientist Award from the Ministry of Health of Ontario.

² Presented as a poster at the 1988 Annual Meeting of the Federation of American Societies for Experimental Biology, May 1, 1988, Las Vegas, NV [Atkinson, S., Shah, J., Webber, C., Gibson, R. S. & Gibson, I. (1988) Bioavailability and tissue uptake of minerals in piglets fed formulas fortified with Ca, P ± Zn, Cu and Fe. FASEB J. 2: 2066 (abs. A652)].

³ To whom correspondence should be addressed.

Manuscript received 29 March 1993. Revision accepted 18 May 1993.

This article has been cited by other articles:

				J. K. Patterson, X. G. Lei, and D. D. Miller The Pig as an Experimental Model for Elucidating the Mechanisms Governing Dietary Influence on Mineral Absorption Experimental Biology and Medicine, June 1, 2008; 233(6): 651 - 664. [Abstract] [Full Text] [PDF]