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Changes in Plasma and Hepatic Lipids, Small Intestinal Histology and Pancreatic Enzyme Activity Due to Aging and Dietary Fiber in Rats^{1, 2,}

Department of Nutrition, University of California, Davis, CA 95616-8669

Rats were fed either a control diet or a control diet supplemented with wheat bran, psyllium husk or oat bran to increase intake of fiber. Groups of rats were killed after 3.5, 10, 15, or 18.5 mo of consuming the diets. Plasma cholesterol and triglyceride concentrations were significantly higher in 18.5-mo-old than younger animals. Fiber supplementation did not prevent the age-related increase in lipids. Cecal weight, including contents, was higher in the psyllium husk and oat bran groups than control, and smooth muscle thickness in the ileum of psyllium husk and oat bran animals was greater than control. The score for torn villi in the small intestine was lower than expected in the wheat bran group. Amylase activity in the pancreas declined significantly with age in all groups. In aging animals fiber supplementation may enhance ileal compensation for decreases in proximal intestinal function but does not prevent age-related changes in the gut or in lipid concentrations.

KEY WORDS: • dietary fiber • gastrointestinal • aging • cholesterol • rats

¹ Supported in part by NIH grant DK20446 and a grant from Kraft-General Foods.

² The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this fact.

Manuscript received 28 October 1992. Revision accepted 18 March 1993.