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Chemical Modifications of Proteins In Vivo: Selected Examples Important to Cellular Regulation¹

Department of Nutrition, University of California at Davis, Davis, CA 95616-8669

The synthesis and degradation pathways for individual proteins and functional peptides often involve numerous co- and post-translational modifying steps. This review focuses on the diversity of such reactions. The reactions are organized into functional categories. An overall goal is to highlight post-translational events as often having the same importance to functional protein production as the transcriptional and translational events that initiate their synthesis.

KEY WORDS: • post-translational protein modifications • cellular regulation • chemical modification of proteins

¹ Support for writing this review came in part from USDA grant 89-37200, U.S. Public Health Service NIH grants HL15965, DK35747 and HD 26777, and a grant from the California Tobacco-Related Disease Program.

² To whom correspondence should be addressed.

Manuscript received 29 October 1992. Revision accepted 29 January 1993.